Daniel K White1, Tuhina Neogi2, W Jack Rejeski3, Michael P Walkup3, Cora E Lewis4, Michael C Nevitt5, Capri G Foy3, David T Felson6. 1. University of Delaware, Newark, and Sargent College, Boston University, Boston, Massachusetts. 2. Boston University School of Medicine, Boston, Massachusetts. 3. Wake Forest University, Winston-Salem, North Carolina. 4. University of Alabama, Birmingham. 5. University of California, San Francisco. 6. Boston University School of Medicine, Boston, Massachusetts, and University of Manchester, Manchester, UK.
Abstract
OBJECTIVE: It is unclear whether an intensive program of weight loss combined with exercise prevents the onset of knee pain among those at high risk. We examined whether an intensive lifestyle intervention (ILI) prevents incident knee pain compared with a diabetes mellitus support and education (DSE) comparison group among overweight adults with diabetes mellitus. METHODS: We conducted a secondary analysis of the Action for Health in Diabetes (Look AHEAD) study, which is a randomized intervention trial of adults who were obese and had type 2 diabetes mellitus starting in 2001. We studied a subcohort of 2,889 subjects who reported no knee pain at baseline but were at high risk due to obesity. Risk ratios (RRs) were calculated to examine the association of ILI versus DSE with incident knee pain at year 1 and year 4. All analyses were adjusted for potential confounders. RESULTS: Age, sex, and body mass index were similar among ILI and DSE participants with no knee pain at baseline. At year 1, ILI participants were 15% less likely to develop knee pain compared with DSE participants (RR 0.85, 95% confidence interval 0.74-0.98). At year 4, this difference decreased to 5% and was no longer statistically significant. CONCLUSION: An ILI of diet and exercise may prevent the development of knee pain among those at high risk in the short term. Health care providers may consider recommending diet and exercise as a means to prevent the development of knee pain among those at high risk.
RCT Entities:
OBJECTIVE: It is unclear whether an intensive program of weight loss combined with exercise prevents the onset of knee pain among those at high risk. We examined whether an intensive lifestyle intervention (ILI) prevents incident knee pain compared with a diabetes mellitus support and education (DSE) comparison group among overweight adults with diabetes mellitus. METHODS: We conducted a secondary analysis of the Action for Health in Diabetes (Look AHEAD) study, which is a randomized intervention trial of adults who were obese and had type 2 diabetes mellitus starting in 2001. We studied a subcohort of 2,889 subjects who reported no knee pain at baseline but were at high risk due to obesity. Risk ratios (RRs) were calculated to examine the association of ILI versus DSE with incident knee pain at year 1 and year 4. All analyses were adjusted for potential confounders. RESULTS: Age, sex, and body mass index were similar among ILI and DSEparticipants with no knee pain at baseline. At year 1, ILI participants were 15% less likely to develop knee pain compared with DSEparticipants (RR 0.85, 95% confidence interval 0.74-0.98). At year 4, this difference decreased to 5% and was no longer statistically significant. CONCLUSION: An ILI of diet and exercise may prevent the development of knee pain among those at high risk in the short term. Health care providers may consider recommending diet and exercise as a means to prevent the development of knee pain among those at high risk.
Authors: Marita Cross; Emma Smith; Damian Hoy; Sandra Nolte; Ilana Ackerman; Marlene Fransen; Lisa Bridgett; Sean Williams; Francis Guillemin; Catherine L Hill; Laura L Laslett; Graeme Jones; Flavia Cicuttini; Richard Osborne; Theo Vos; Rachelle Buchbinder; Anthony Woolf; Lyn March Journal: Ann Rheum Dis Date: 2014-02-19 Impact factor: 19.103
Authors: John M Jakicic; Edward Gregg; William Knowler; David E Kelley; Wei Lang; Gary D Miller; F Xavier Pi-Sunyer; Judith G Regensteiner; W Jack Rejeski; Paul Ridisl; Michael P Walkup; Donna L Wolf Journal: Med Sci Sports Exerc Date: 2010-11 Impact factor: 5.411
Authors: Stephen P Messier; Richard F Loeser; Gary D Miller; Timothy M Morgan; W Jack Rejeski; Mary Ann Sevick; Walter H Ettinger; Marco Pahor; Jeff D Williamson Journal: Arthritis Rheum Date: 2004-05
Authors: Donna H Ryan; Mark A Espeland; Gary D Foster; Steven M Haffner; Van S Hubbard; Karen C Johnson; Steven E Kahn; William C Knowler; Susan Z Yanovski Journal: Control Clin Trials Date: 2003-10
Authors: Richard P Troiano; David Berrigan; Kevin W Dodd; Louise C Mâsse; Timothy Tilert; Margaret McDowell Journal: Med Sci Sports Exerc Date: 2008-01 Impact factor: 5.411
Authors: Xavier Pi-Sunyer; George Blackburn; Frederick L Brancati; George A Bray; Renee Bright; Jeanne M Clark; Jeffrey M Curtis; Mark A Espeland; John P Foreyt; Kathryn Graves; Steven M Haffner; Barbara Harrison; James O Hill; Edward S Horton; John Jakicic; Robert W Jeffery; Karen C Johnson; Steven Kahn; David E Kelley; Abbas E Kitabchi; William C Knowler; Cora E Lewis; Barbara J Maschak-Carey; Brenda Montgomery; David M Nathan; Jennifer Patricio; Anne Peters; J Bruce Redmon; Rebecca S Reeves; Donna H Ryan; Monika Safford; Brent Van Dorsten; Thomas A Wadden; Lynne Wagenknecht; Jacqueline Wesche-Thobaben; Rena R Wing; Susan Z Yanovski Journal: Diabetes Care Date: 2007-03-15 Impact factor: 19.112
Authors: D T Felson; R C Lawrence; P A Dieppe; R Hirsch; C G Helmick; J M Jordan; R S Kington; N E Lane; M C Nevitt; Y Zhang; M Sowers; T McAlindon; T D Spector; A R Poole; S Z Yanovski; G Ateshian; L Sharma; J A Buckwalter; K D Brandt; J F Fries Journal: Ann Intern Med Date: 2000-10-17 Impact factor: 25.391
Authors: Daniel K White; Tuhina Neogi; Yuqing Zhang; David Felson; Michael Lavalley; Jingbo Niu; Michael Nevitt; Cora E Lewis; James Torner; K Douglas Gross Journal: J Obes Date: 2012-05-07
Authors: Jing-Sheng Li; Tsung-Yuan Tsai; Margaret M Clancy; Guoan Li; Cara L Lewis; David T Felson Journal: Gait Posture Date: 2018-12-24 Impact factor: 2.840
Authors: D Felson; G Rabasa; S R Jafarzadeh; M Nevitt; C E Lewis; N Segal; D K White Journal: Osteoarthritis Cartilage Date: 2021-04-24 Impact factor: 7.507
Authors: Kaitlyn M Berry; Tuhina Neogi; Joshua F Baker; Jason M Collins; Jason R Waggoner; Chia-Wen Hsiao; Stephen S Johnston; Michael P LaValley; Andrew C Stokes Journal: Arthritis Care Res (Hoboken) Date: 2021-03 Impact factor: 4.794
Authors: Phyllis A Richey; Karen C Johnson; Rebecca H Neiberg; Judy L Bahnson; Kunal Singhal; Mace Coday; Fridtjof Thomas; Cora E Lewis; William M Mihalko Journal: J Arthroplasty Date: 2020-02-19 Impact factor: 4.757