Sara Irani1, M Mahmood Hussain. 1. aSchool of Graduate Studies, Molecular and Cell Biology Program bDepartment of Cell Biology cDepartment of Pediatrics, SUNY Downstate Medical Center dVA New York Harbor Healthcare System, Brooklyn, New York, USA.
Abstract
PURPOSE OF REVIEW: To summarize the role of the microRNA-30c (miR-30c) in lipid metabolism and adipogenesis, to address consequences associated with reduced expression in cancer and cardiac function, and to speculate benefits of overexpressing miR-30c in the treatment of hyperlipidemia, atherosclerosis, and cancer. RECENT FINDINGS: Overexpression of hepatic miR-30c curtails hyperlipidemia and atherosclerosis by decreasing lipid biosynthesis and lipoprotein secretion. miR-30c expression is significantly elevated during cellular adipogenesis and might play a pro-adipogenic role by up-regulating the expression of adipocyte markers and inducing lipid accumulation. miR-30c is downregulated in cardiac hypertrophy and ischemia, indicating that its expression might be essential for normal cardiac structure and function. Many studies have demonstrated that miR-30c is lower in cancer and its high expression impedes cancer progression by targeting genes involved in cell proliferation and invasion. SUMMARY: These studies highlight the important role miR-30c plays in lipid metabolism, adipogenesis, and cell proliferation and differentiation. Further, they point to pathologic outcomes associated with reduced expression in cancer and cardiac hypertrophy. Additionally, they suggest that increasing miR-30c expression in the liver and cancerous tissue might reduce hyperlipidemia and atherosclerosis, and cancer progression and metastasis, respectively. Studies are needed to evaluate the efficacy of miR-30c mimic in the treatment of these disorders.
PURPOSE OF REVIEW: To summarize the role of the microRNA-30c (miR-30c) in lipid metabolism and adipogenesis, to address consequences associated with reduced expression in cancer and cardiac function, and to speculate benefits of overexpressing miR-30c in the treatment of hyperlipidemia, atherosclerosis, and cancer. RECENT FINDINGS: Overexpression of hepatic miR-30c curtails hyperlipidemia and atherosclerosis by decreasing lipid biosynthesis and lipoprotein secretion. miR-30c expression is significantly elevated during cellular adipogenesis and might play a pro-adipogenic role by up-regulating the expression of adipocyte markers and inducing lipid accumulation. miR-30c is downregulated in cardiac hypertrophy and ischemia, indicating that its expression might be essential for normal cardiac structure and function. Many studies have demonstrated that miR-30c is lower in cancer and its high expression impedes cancer progression by targeting genes involved in cell proliferation and invasion. SUMMARY: These studies highlight the important role miR-30c plays in lipid metabolism, adipogenesis, and cell proliferation and differentiation. Further, they point to pathologic outcomes associated with reduced expression in cancer and cardiac hypertrophy. Additionally, they suggest that increasing miR-30c expression in the liver and cancerous tissue might reduce hyperlipidemia and atherosclerosis, and cancer progression and metastasis, respectively. Studies are needed to evaluate the efficacy of miR-30c mimic in the treatment of these disorders.
Authors: Jin Xue; Dan Zhou; Orit Poulsen; Iain Hartley; Toshihiro Imamura; Edward X Xie; Gabriel G Haddad Journal: Physiol Genomics Date: 2018-07-20 Impact factor: 3.107
Authors: Troels K H Scheel; Michael J Moore; Joseph M Luna; Eiko Nishiuchi; John Fak; Robert B Darnell; Charles M Rice Journal: Sci Rep Date: 2017-08-15 Impact factor: 4.379