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Literature DB >> 25692283

APTEC: aptamer-tethered enzyme capture as a novel rapid diagnostic test for malaria.

Roderick M Dirkzwager¹, Andrew B Kinghorn, Jack S Richards, Julian A Tanner.

Abstract

We report the rapid diagnosis of malaria by aptamer-tethered enzyme capture (APTEC) whereby an aptamer captures biomarker Plasmodium falciparum lactate dehydrogenase (PfLDH) then activity is measured colorimetrically. The robust test was sensitive (limit of detection = 4.9 ng mL(-1)) and could reliably diagnose malaria in clinical blood samples.

Entities: Disease Species

Mesh：

Substances：

Year: 2015 PMID： 25692283 DOI： 10.1039/c5cc00438a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

9 in total

1. Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.

Authors: Yee-Wai Cheung; Pascal Röthlisberger; Ariel E Mechaly; Patrick Weber; Fabienne Levi-Acobas; Young Lo; Alvin W C Wong; Andrew B Kinghorn; Ahmed Haouz; G Paul Savage; Marcel Hollenstein; Julian A Tanner
Journal: Proc Natl Acad Sci U S A Date: 2020-07-06 Impact factor: 11.205

2. Activity-based assessment of an engineered hyperthermophilic protein as a capture agent in paper-based diagnostic tests.

Authors: E A Miller; M W Traxlmayr; J Shen; H D Sikes
Journal: Mol Syst Des Eng Date: 2016-06-29

3. A microfluidic paper analytical device using capture aptamers for the detection of PfLDH in blood matrices.

Authors: Adewoyin Martin Ogunmolasuyi; Ronen Fogel; Heinrich Hoppe; Dean Goldring; Janice Limson
Journal: Malar J Date: 2022-06-07 Impact factor: 3.469

4. Aromatic Surfactant as Aggregating Agent for Aptamer-Gold Nanoparticle-Based Detection of Plasmodium Lactate Dehydrogenase.

Authors: Priyamvada Jain; Babina Chakma; Naveen Kumar Singh; Sanjukta Patra; Pranab Goswami
Journal: Mol Biotechnol Date: 2016-07 Impact factor: 2.695

5. A DNA aptamer recognising a malaria protein biomarker can function as part of a DNA origami assembly.

Authors: Maia Godonoga; Ting-Yu Lin; Azusa Oshima; Koji Sumitomo; Marco S L Tang; Yee-Wai Cheung; Andrew B Kinghorn; Roderick M Dirkzwager; Cunshan Zhou; Akinori Kuzuya; Julian A Tanner; Jonathan G Heddle
Journal: Sci Rep Date: 2016-02-19 Impact factor: 4.379

APTEC: aptamer-tethered enzyme capture as a novel rapid diagnostic test for malaria.

1. Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.

2. Activity-based assessment of an engineered hyperthermophilic protein as a capture agent in paper-based diagnostic tests.

3. A microfluidic paper analytical device using capture aptamers for the detection of PfLDH in blood matrices.

4. Aromatic Surfactant as Aggregating Agent for Aptamer-Gold Nanoparticle-Based Detection of Plasmodium Lactate Dehydrogenase.

5. A DNA aptamer recognising a malaria protein biomarker can function as part of a DNA origami assembly.

6. DNA aptamers for the recognition of HMGB1 from Plasmodium falciparum.

7. Randomly positioned gold nanoparticles as fluorescence enhancers in apta-immunosensor for malaria test.

8. Addressing Barriers to the Development and Adoption of Rapid Diagnostic Tests in Global Health.

9. Aptamer Display on Diverse DNA Polyhedron Supports.