| Literature DB >> 25691645 |
Irene Rodríguez1, Ângela Novais2, Felipe Lira3, Aránzazu Valverde4, Tânia Curião1, José Luis Martínez3, Fernando Baquero1, Rafael Cantón5, Teresa M Coque6.
Abstract
We describe the genetic background of bla(TEM-4) and the complete sequence of pRYC11::bla(TEM-4), a mosaic plasmid that is highly similar to pKpQIL-like variants, predominant among TEM-4 producers in a Spanish hospital (1990 to 2004), which belong to Klebsiella pneumoniae and Escherichia coli high-risk clones responsible for the current spread of different antibiotic resistance genes. Predominant populations of plasmids and host adapted clonal lineages seem to have greatly contributed to the spread of resistance to extended-spectrum cephalosporins.Entities:
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Year: 2015 PMID: 25691645 PMCID: PMC4394812 DOI: 10.1128/AAC.00296-15
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191