OBJECTIVE: The aim of this study was to determine whether the brain-derived neurotrophic factor ( BDNF) 196 G/A or catechol- O-methyltransferase ( COMT) Val158Met polymorphisms is associated with susceptibility to ADHD. METHOD: We conducted a meta-analysis of the associations between the BDNF 196 G/A and COMT Val158Met polymorphisms and ADHD. RESULTS: Sixteen studies consisting of 3,594 patients with ADHD and 4,040 controls were included in this meta-analysis. Our results showed no association between ADHD and the BDNF 196A allele in all participants (odds ratio [OR] = 0.958, 95% confidence interval [CI] = [0.800, 1.146], p = .638), European or Asian population. Meta-analysis indicated no association between ADHD and the COMT G allele in all study participants (OR = 1.078, 95% CI = [0.962, 1.207], p = .196), European or Asian population. CONCLUSION: This meta-analysis showed a lack of association between the BDNF 196 G/A and COMT Val158Met polymorphisms and ADHD.
OBJECTIVE: The aim of this study was to determine whether the brain-derived neurotrophic factor ( BDNF) 196 G/A or catechol- O-methyltransferase ( COMT) Val158Met polymorphisms is associated with susceptibility to ADHD. METHOD: We conducted a meta-analysis of the associations between the BDNF196 G/A and COMT Val158Met polymorphisms and ADHD. RESULTS: Sixteen studies consisting of 3,594 patients with ADHD and 4,040 controls were included in this meta-analysis. Our results showed no association between ADHD and the BDNF 196A allele in all participants (odds ratio [OR] = 0.958, 95% confidence interval [CI] = [0.800, 1.146], p = .638), European or Asian population. Meta-analysis indicated no association between ADHD and the COMT G allele in all study participants (OR = 1.078, 95% CI = [0.962, 1.207], p = .196), European or Asian population. CONCLUSION: This meta-analysis showed a lack of association between the BDNF196 G/A and COMT Val158Met polymorphisms and ADHD.
Authors: Glaucia C Akutagava-Martins; Angelica Salatino-Oliveira; Christian Kieling; Julia P Genro; Guilherme V Polanczyk; Luciana Anselmi; Ana M B Menezes; Helen Gonçalves; Fernando C Wehrmeister; Fernando C Barros; Sidia M Callegari-Jacques; Luis A Rohde; Mara H Hutz Journal: J Psychiatry Neurosci Date: 2016-10 Impact factor: 6.186
Authors: N S Corral-Frías; D A Pizzagalli; J M Carré; L J Michalski; Y S Nikolova; R H Perlis; J Fagerness; M R Lee; E Drabant Conley; T M Lancaster; S Haddad; A Wolf; J W Smoller; A R Hariri; R Bogdan Journal: Genes Brain Behav Date: 2016-06 Impact factor: 3.449
Authors: Sabina K Millenet; Frauke Nees; Stefan Heintz; Christiane Bach; Josef Frank; Sabine Vollstädt-Klein; Arun Bokde; Uli Bromberg; Christian Büchel; Erin B Quinlan; Sylvane Desrivières; Juliane Fröhner; Herta Flor; Vincent Frouin; Hugh Garavan; Penny Gowland; Andreas Heinz; Bernd Ittermann; Herve Lemaire; Jean-Luc Martinot; Marie-Laure P Martinot; Dimitri O Papadoulos; Tomáš Paus; Luise Poustka; Marcella Rietschel; Michael N Smolka; Henrik Walter; Rob Whelan; Gunter Schumann; Tobias Banaschewski; Sarah Hohmann Journal: Front Genet Date: 2018-07-31 Impact factor: 4.599