PURPOSE: To investigate the differences in brain glucose consumption during olfactory stimulation between subjects affected by multiple chemical sensitivity (MCS) and a group of healthy individuals. METHODS: Two (18)F-FDG PET/CT scans were performed in 26 subjects (6 men and 20 women; mean age 46.7 ± 11 years) with a clinical diagnosis of MCS and in 11 healthy controls (6 women and 5 men; mean age 45.7 ± 11 years), the first scan after a neutral olfactory stimulation (NS) and the second after a pure olfactory stimulation (OS). Differences in (18)F-FDG uptake were analysed by statistical parametric mapping (SPM2). RESULTS: In controls OS led to an increase in glucose consumption in BA 18 and 19 and a reduction in glucose metabolism in BA 10, 11, 32 and 47. In MCS subjects, OS led to an increase in glucose consumption in BA 20, 23, 18 and 37 and a reduction in glucose metabolism in BA 8, 9 and 10. CONCLUSION: The results of our study suggest that cortical activity in subjects with MCS differs from that in healthy individuals during olfactory stimulation.
PURPOSE: To investigate the differences in brain glucose consumption during olfactory stimulation between subjects affected by multiple chemical sensitivity (MCS) and a group of healthy individuals. METHODS: Two (18)F-FDG PET/CT scans were performed in 26 subjects (6 men and 20 women; mean age 46.7 ± 11 years) with a clinical diagnosis of MCS and in 11 healthy controls (6 women and 5 men; mean age 45.7 ± 11 years), the first scan after a neutral olfactory stimulation (NS) and the second after a pure olfactory stimulation (OS). Differences in (18)F-FDG uptake were analysed by statistical parametric mapping (SPM2). RESULTS: In controls OS led to an increase in glucose consumption in BA 18 and 19 and a reduction in glucose metabolism in BA 10, 11, 32 and 47. In MCS subjects, OS led to an increase in glucose consumption in BA 20, 23, 18 and 37 and a reduction in glucose metabolism in BA 8, 9 and 10. CONCLUSION: The results of our study suggest that cortical activity in subjects with MCS differs from that in healthy individuals during olfactory stimulation.
Authors: Julie A Boyle; Jelena Djordjevic; Mats J Olsson; Johan N Lundström; Marilyn Jones-Gotman Journal: Cereb Cortex Date: 2008-04-28 Impact factor: 5.357
Authors: Thomas M Dantoft; Sine Skovbjerg; Linus Andersson; Anna-Sara Claeson; Kaare Engkilde; Nina Lind; Steven Nordin; Lars I Hellgren Journal: BMJ Open Date: 2017-02-22 Impact factor: 2.692
Authors: Marco Pagani; Gianluca Castelnuovo; Andrea Daverio; Patrizia La Porta; Leonardo Monaco; Fabiola Ferrentino; Agostino Chiaravalloti; Isabel Fernandez; Giorgio Di Lorenzo Journal: Front Psychol Date: 2018-04-16