| Literature DB >> 25689430 |
Hiyoung Kim1, Inho Yang1, Shin-Young Ryu2, Dong Hwan Won1, Awadut G Giri1, Weihong Wang1, Hyukjae Choi3, Jungwook Chin1, Dongyup Hahn1, Eunhee Kim1, Chulkyeong Han1, Jihye Lee1, Sang-Jip Nam4, Won-Kyung Ho2, Heonjoong Kang1,5.
Abstract
Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K(+) currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 μM, respectively.Entities:
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Year: 2015 PMID： 25689430 DOI： 10.1021/np5007586
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050