L J Djukić1, J Roganović1, M D Brajović2, D Bokonjić3, D Stojić1. 1. Department of Pharmacology in Dentistry, School of Dental Medicine, University of Belgrade, Belgrade, Serbia. 2. Department of Cardiology, Zvezdara University Hospital, Belgrade, Serbia. 3. Military Medical Academy, National Poison Control Centre, Belgrade, Serbia.
Abstract
OBJECTIVE: The present cross-sectional study aimed to determine the effect of first-line anti-hypertensive drugs (enalapril, metoprolol, and combinations of enalapril with metoprolol and/or hydrochlorothiazide) on salivary gland function and salivary total antioxidant capacity (TAC) in hypertensive patients with/without diabetes mellitus (DM) type 2. MATERIALS AND METHODS:Salivary gland function was measured as xerostomia (interview) and unstimulated whole saliva flow rate (UWSFR) in 447 subjects (387 hypertensive and 60 healthy). Salivary TAC was evaluated by spectrophotometric assay. RESULTS:Enalapril is not xerogenic, while metoprolol and drug combinations are. In the presence of DM type 2, all drugs, except metoprolol, had pronounced xerogenic effect. Binary logistic regression analysis found enalapril to be significantly associated with decreased risk of xerogenic effect development, while DM type 2 with increased risk. In the presence of enalapril in hypertensive patients with/without DM type 2salivary TAC was similar to that in healthy subjects, while for metoprolol was reduced. CONCLUSIONS:Enalapril is not xerogenic but is antioxidant, which moderately reduces the risk of xerogenic effect development even in the presence of DM type 2. However, metoprolol and drug combinations exhibit xerogenic effect. In DM type 2, xerogenic effect of all drugs was pronounced except of metoprolol.
RCT Entities:
OBJECTIVE: The present cross-sectional study aimed to determine the effect of first-line anti-hypertensive drugs (enalapril, metoprolol, and combinations of enalapril with metoprolol and/or hydrochlorothiazide) on salivary gland function and salivary total antioxidant capacity (TAC) in hypertensivepatients with/without diabetes mellitus (DM) type 2. MATERIALS AND METHODS: Salivary gland function was measured as xerostomia (interview) and unstimulated whole saliva flow rate (UWSFR) in 447 subjects (387 hypertensive and 60 healthy). Salivary TAC was evaluated by spectrophotometric assay. RESULTS:Enalapril is not xerogenic, while metoprolol and drug combinations are. In the presence of DM type 2, all drugs, except metoprolol, had pronounced xerogenic effect. Binary logistic regression analysis found enalapril to be significantly associated with decreased risk of xerogenic effect development, while DM type 2 with increased risk. In the presence of enalapril in hypertensivepatients with/without DM type 2 salivary TAC was similar to that in healthy subjects, while for metoprolol was reduced. CONCLUSIONS:Enalapril is not xerogenic but is antioxidant, which moderately reduces the risk of xerogenic effect development even in the presence of DM type 2. However, metoprolol and drug combinations exhibit xerogenic effect. In DM type 2, xerogenic effect of all drugs was pronounced except of metoprolol.
Authors: X Wang; P Serrano Martinez; J H Terpstra; A Shaalan; G B Proctor; F K L Spijkervet; A Vissink; H Bootsma; F G M Kroese; R P Coppes; S Pringle Journal: Stem Cell Reports Date: 2021-10-21 Impact factor: 7.765
Authors: Lucía Ramírez Martínez-Acitores; Fernando Hernández Ruiz de Azcárate; Elisabeth Casañas; Julia Serrano; Gonzalo Hernández; Rosa María López-Pintor Journal: Int J Environ Res Public Health Date: 2020-04-05 Impact factor: 3.390