Literature DB >> 2568884

Loss of heterozygosity on 3p in a renal cell carcinoma in von Hippel-Lindau syndrome.

H J Decker1, R M Gemmill, H P Neumann, T A Walter, A A Sandberg.   

Abstract

A renal cell carcinoma with an unbalanced t(X;3) in a patient with von Hippel-Lindau (VHL) syndrome has previously been reported. This rearrangement suggested loss of genetic material from the short arm of chromosome 3, which we are now able to confirm by restriction fragment length polymorphism analysis of tumor DNA using polymorphic probes derived from 3p. The VHL gene has recently been mapped to 3p, therefore loss of this region in this VHL-related renal cell carcinoma may have cogent significance for tumor development in this interesting cancer-predisposing syndrome.

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Year:  1989        PMID： 2568884     DOI： 10.1016/0165-4608(89)90194-5

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  4 in total

1.  Detection of a germline mutation and somatic homozygous loss of the von Hippel-Lindau tumor-suppressor gene in a family with a de novo mutation. A combined genetic study, including cytogenetics, PCR/SSCP, FISH, and CGH.

Authors:  H J Decker; C Neuhaus; A Jauch; M Speicher; T Ried; M Bujard; H Brauch; S Störkel; M Stöckle; B Seliger; C Huber
Journal:  Hum Genet       Date:  1996-06       Impact factor: 4.132

2.  Loss of heterozygosity on chromosome 11 in sporadic gastrinomas.

Authors:  M P Sawicki; Y J Wan; C L Johnson; J Berenson; R Gatti; E Passaro
Journal:  Hum Genet       Date:  1992-06       Impact factor: 4.132

3.  Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease: analysis of allele loss in VHL tumours.

Authors:  P A Crossey; K Foster; F M Richards; M E Phipps; F Latif; K Tory; M H Jones; E Bentley; R Kumar; M I Lerman
Journal:  Hum Genet       Date:  1994-01       Impact factor: 4.132

4.  Central nervous system lesions in von Hippel-Lindau syndrome.

Authors:  H P Neumann; H R Eggert; R Scheremet; M Schumacher; M Mohadjer; A K Wakhloo; B Volk; U Hettmannsperger; P Riegler; P Schollmeyer
Journal:  J Neurol Neurosurg Psychiatry       Date:  1992-10       Impact factor: 10.154
  4 in total

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