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Literature DB >> 25688405

Revisiting tissue specificity of germline cancer predisposing mutations.

Abstract

Heritable germline mutations in major cancer genes generally lead to a restricted pattern of tissue-specific malignancies, yet many of the same mutations frequently occur somatically in a broad range of spontaneous neoplasms affecting different organs. Might this reflect a difference in tumorigenesis in children and adults?

Entities: Disease Species

Mesh：

Substances：

Year: 2015 PMID： 25688405 DOI： 10.1038/nrc3894

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

15 in total

1. Rare variants in TP53 and susceptibility to neuroblastoma.

Authors: Sharon J Diskin; Mario Capasso; Maura Diamond; Derek A Oldridge; Karina Conkrite; Kristopher R Bosse; Mike R Russell; Achille Iolascon; Hakon Hakonarson; Marcella Devoto; John M Maris
Journal: J Natl Cancer Inst Date: 2014-03-14 Impact factor: 13.506

2. A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.

Authors: Simon N Stacey; Patrick Sulem; Aslaug Jonasdottir; Gisli Masson; Julius Gudmundsson; Daniel F Gudbjartsson; Olafur T Magnusson; Sigurjon A Gudjonsson; Bardur Sigurgeirsson; Kristin Thorisdottir; Rafn Ragnarsson; Kristrun R Benediktsdottir; Bjørn A Nexø; Anne Tjønneland; Kim Overvad; Peter Rudnai; Eugene Gurzau; Kvetoslava Koppova; Kari Hemminki; Cristina Corredera; Victoria Fuentelsaz; Pilar Grasa; Sebastian Navarrete; Fernando Fuertes; Maria D García-Prats; Enrique Sanambrosio; Angeles Panadero; Ana De Juan; Almudena Garcia; Fernando Rivera; Dolores Planelles; Virtudes Soriano; Celia Requena; Katja K Aben; Michelle M van Rossum; Ruben G H M Cremers; Inge M van Oort; Dick-Johan van Spronsen; Jack A Schalken; Wilbert H M Peters; Brian T Helfand; Jenny L Donovan; Freddie C Hamdy; Daniel Badescu; Ovidiu Codreanu; Mariana Jinga; Irma E Csiki; Vali Constantinescu; Paula Badea; Ioan N Mates; Daniela E Dinu; Adrian Constantin; Dana Mates; Sjofn Kristjansdottir; Bjarni A Agnarsson; Eirikur Jonsson; Rosa B Barkardottir; Gudmundur V Einarsson; Fridbjorn Sigurdsson; Pall H Moller; Tryggvi Stefansson; Trausti Valdimarsson; Oskar T Johannsson; Helgi Sigurdsson; Thorvaldur Jonsson; Jon G Jonasson; Laufey Tryggvadottir; Terri Rice; Helen M Hansen; Yuanyuan Xiao; Daniel H Lachance; Brian Patrick O Neill; Matthew L Kosel; Paul A Decker; Gudmar Thorleifsson; Hrefna Johannsdottir; Hafdis T Helgadottir; Asgeir Sigurdsson; Valgerdur Steinthorsdottir; Annika Lindblom; Robert S Sandler; Temitope O Keku; Karina Banasik; Torben Jørgensen; Daniel R Witte; Torben Hansen; Oluf Pedersen; Viorel Jinga; David E Neal; William J Catalona; Margaret Wrensch; John Wiencke; Robert B Jenkins; Eduardo Nagore; Ulla Vogel; Lambertus A Kiemeney; Rajiv Kumar; José I Mayordomo; Jon H Olafsson; Augustine Kong; Unnur Thorsteinsdottir; Thorunn Rafnar; Kari Stefansson
Journal: Nat Genet Date: 2011-09-25 Impact factor: 38.330

Review 3. The search for the retinoblastoma cell of origin.

Authors: Michael A Dyer; Rod Bremner
Journal: Nat Rev Cancer Date: 2005-02 Impact factor: 60.716

4. Mutation and cancer: neuroblastoma and pheochromocytoma.

Authors: A G Knudson; L C Strong
Journal: Am J Hum Genet Date: 1972-09 Impact factor: 11.025

Review 5. Cancer genome landscapes.

Authors: Bert Vogelstein; Nickolas Papadopoulos; Victor E Velculescu; Shibin Zhou; Luis A Diaz; Kenneth W Kinzler
Journal: Science Date: 2013-03-29 Impact factor: 47.728

6. The first knockout mouse model of retinoblastoma.

Authors: Jiakun Zhang; Brett Schweers; Michael A Dyer
Journal: Cell Cycle Date: 2004-07-03 Impact factor: 4.534

7. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.

Authors: D Malkin; F P Li; L C Strong; J F Fraumeni; C E Nelson; D H Kim; J Kassel; M A Gryka; F Z Bischoff; M A Tainsky
Journal: Science Date: 1990-11-30 Impact factor: 47.728

8. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma.

Authors: S H Friend; R Bernards; S Rogelj; R A Weinberg; J M Rapaport; D M Albert; T P Dryja
Journal: Nature Date: 1986 Oct 16-22 Impact factor: 49.962

9. A novel retinoblastoma therapy from genomic and epigenetic analyses.

Authors: Jinghui Zhang; Claudia A Benavente; Justina McEvoy; Jacqueline Flores-Otero; Li Ding; Xiang Chen; Anatoly Ulyanov; Gang Wu; Matthew Wilson; Jianmin Wang; Rachel Brennan; Michael Rusch; Amity L Manning; Jing Ma; John Easton; Sheila Shurtleff; Charles Mullighan; Stanley Pounds; Suraj Mukatira; Pankaj Gupta; Geoff Neale; David Zhao; Charles Lu; Robert S Fulton; Lucinda L Fulton; Xin Hong; David J Dooling; Kerri Ochoa; Clayton Naeve; Nicholas J Dyson; Elaine R Mardis; Armita Bahrami; David Ellison; Richard K Wilson; James R Downing; Michael A Dyer
Journal: Nature Date: 2012-01-11 Impact factor: 49.962

Revisiting tissue specificity of germline cancer predisposing mutations.

1. Rare variants in TP53 and susceptibility to neuroblastoma.

2. A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.

Review 3. The search for the retinoblastoma cell of origin.

4. Mutation and cancer: neuroblastoma and pheochromocytoma.

Review 5. Cancer genome landscapes.

6. The first knockout mouse model of retinoblastoma.

7. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.

8. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma.

9. A novel retinoblastoma therapy from genomic and epigenetic analyses.

10. Rb suppresses human cone-precursor-derived retinoblastoma tumours.

1. Clinical Features of Children with Retinoblastoma and Neuroblastoma.

Review 2. The not-so-sweet side of sugar: Influence of the microenvironment on the processes that unleash cancer.

3. A benchmark of gene expression tissue-specificity metrics.

4. Depicting the genetic architecture of pediatric cancers through an integrative gene network approach.

Review 5. Potential Second-Hits in Hereditary Hemorrhagic Telangiectasia.