Literature DB >> 25687907

Targeted therapies: DNA polymerase θ-a new target for synthetic lethality?

David Killock.   

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Year:  2015        PMID： 25687907     DOI： 10.1038/nrclinonc.2015.23

Source DB:  PubMed          Journal:  Nat Rev Clin Oncol        ISSN： 1759-4774            Impact factor:   66.675


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  2 in total

1.  Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination.

Authors:  Pedro A Mateos-Gomez; Fade Gong; Nidhi Nair; Kyle M Miller; Eros Lazzerini-Denchi; Agnel Sfeir
Journal:  Nature       Date:  2015-02-02       Impact factor: 49.962

2.  Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.

Authors:  Raphael Ceccaldi; Jessica C Liu; Ravindra Amunugama; Ildiko Hajdu; Benjamin Primack; Mark I R Petalcorin; Kevin W O'Connor; Panagiotis A Konstantinopoulos; Stephen J Elledge; Simon J Boulton; Timur Yusufzai; Alan D D'Andrea
Journal:  Nature       Date:  2015-02-02       Impact factor: 69.504
  2 in total
  8 in total

Review 1.  Paths from DNA damage and signaling to genome rearrangements via homologous recombination.

Authors:  Jac A Nickoloff
Journal:  Mutat Res       Date:  2017-07-24       Impact factor: 3.151

2.  Dual loss of human POLQ and LIG4 abolishes random integration.

Authors:  Shinta Saito; Ryo Maeda; Noritaka Adachi
Journal:  Nat Commun       Date:  2017-07-11       Impact factor: 14.919

Review 3.  Natural products targeting cancer cell dependency.

Authors:  Changxiang Shi; Eun Ju Yang; Shishi Tao; Guowen Ren; Pui Kei Mou; Joong Sup Shim
Journal:  J Antibiot (Tokyo)       Date:  2021-06-23       Impact factor: 2.649

4.  Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy.

Authors:  Jac A Nickoloff; Lynn Taylor; Neelam Sharma; Takamitsu A Kato
Journal:  Cancer Drug Resist       Date:  2021-06-19

Review 5.  Drugging the Cancers Addicted to DNA Repair.

Authors:  Jac A Nickoloff; Dennie Jones; Suk-Hee Lee; Elizabeth A Williamson; Robert Hromas
Journal:  J Natl Cancer Inst       Date:  2017-11-01       Impact factor: 11.816

6.  Mutational signatures of non-homologous and polymerase theta-mediated end-joining in embryonic stem cells.

Authors:  Joost Schimmel; Hanneke Kool; Robin van Schendel; Marcel Tijsterman
Journal:  EMBO J       Date:  2017-10-27       Impact factor: 11.598

Review 7.  Ionizing Radiation and Complex DNA Damage: Quantifying the Radiobiological Damage Using Monte Carlo Simulations.

Authors:  Konstantinos P Chatzipapas; Panagiotis Papadimitroulas; Dimitris Emfietzoglou; Spyridon A Kalospyros; Megumi Hada; Alexandros G Georgakilas; George C Kagadis
Journal:  Cancers (Basel)       Date:  2020-03-26       Impact factor: 6.639

8.  Distinct roles of structure-specific endonucleases EEPD1 and Metnase in replication stress responses.

Authors:  Neelam Sharma; Michael C Speed; Christopher P Allen; David G Maranon; Elizabeth Williamson; Sudha Singh; Robert Hromas; Jac A Nickoloff
Journal:  NAR Cancer       Date:  2020-06-08
  8 in total

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