AIM: To assess whether DNA methylation is associated with coronary artery disease (CAD). MATERIALS & METHODS: An epigenome-wide analysis has been performed on leucocytes from familial hypercholesterolemic (FH) men with (n = 6) or without CAD (n = 6). The results were replicated in an extended sample of FH men (n = 61) and in non-FH men (n = 100) for two of the top differentially methylated loci. RESULTS: FH men with CAD had significantly more hypomethylated and hypermethylated loci and showed less DNA methylation level variability compared with men without CAD (p < 0.001). Moreover, COL14A1 and MMP9 DNA methylation levels were associated with CAD, age of onset of CAD or CAD risk factors. CONCLUSION: These results suggest that epigenome-wide changes are associated with CAD occurrence in men.
AIM: To assess whether DNA methylation is associated with coronary artery disease (CAD). MATERIALS & METHODS: An epigenome-wide analysis has been performed on leucocytes from familial hypercholesterolemic (FH) men with (n = 6) or without CAD (n = 6). The results were replicated in an extended sample of FH men (n = 61) and in non-FH men (n = 100) for two of the top differentially methylated loci. RESULTS: FH men with CAD had significantly more hypomethylated and hypermethylated loci and showed less DNA methylation level variability compared with men without CAD (p < 0.001). Moreover, COL14A1 and MMP9 DNA methylation levels were associated with CAD, age of onset of CAD or CAD risk factors. CONCLUSION: These results suggest that epigenome-wide changes are associated with CAD occurrence in men.
Entities:
Keywords:
DNA methylation; arterial remodeling; candidate genes; cardiovascular diseases; epigenome-wide association study; gene expression; missing heritability
Authors: Chih-Hsu Lin; Daniel M Konecki; Meng Liu; Stephen J Wilson; Huda Nassar; Angela D Wilkins; David F Gleich; Olivier Lichtarge Journal: Bioinformatics Date: 2019-05-01 Impact factor: 6.937
Authors: Geoffrey Istas; Ken Declerck; Maria Pudenz; Katarzyna Szarc Vel Szic; Veronica Lendinez-Tortajada; Montserrat Leon-Latre; Karen Heyninck; Guy Haegeman; Jose A Casasnovas; Maria Tellez-Plaza; Clarissa Gerhauser; Christian Heiss; Ana Rodriguez-Mateos; Wim Vanden Berghe Journal: Sci Rep Date: 2017-07-11 Impact factor: 4.379