Literature DB >> 25687254

Rapid spread of Clostridium difficile NAP1/027/ST1 in Chile confirms the emergence of the epidemic strain in Latin America.

C Aguayo1, R Flores2, S Lévesque3, P Araya2, S Ulloa1, J Lagos1, J C Hormazabal2, J Tognarelli1, D Ibáñez2, P Pidal2, O Duery2, B Olivares1, J Fernández1.   

Abstract

Clostridium difficile infection has gained importance in recent years as a result of the rapid spread of epidemic strains, including hypervirulent strains. This study reports the molecular epidemiology of C. difficile obtained from hospitalized patients in Chile. Seven hundred and nineteen isolates of toxigenic C. difficile from 45 hospitals across the country were characterized through toxin profile, pulsed-field gel electrophoresis (PFGE), and sequencing of the tcdC gene. In addition, polymerase chain reaction (PCR) ribotyping and multilocus sequence typing (MLST) were performed on a subset of selected strains. PFGE typing of 719 isolates of C. difficile produced 60 PFGE patterns (subtypes). Subtype 1 was predominant (79% of isolates) and related to the hypervirulent strain (NAP1). Subtype 1 showed 73% relatedness with nine other subtypes, which had a similar tcdC deletion. Subtype 1 corresponded to ribotype 027 and ST1. This report shows the wide dissemination of the hypervirulent strain NAP1/027/ST1 in Chile.

Entities:  

Keywords:  Clostridium difficile; MLST; PFGE; ribotype

Mesh：

Substances：

Year:  2015        PMID： 25687254      PMCID： PMC9151021          DOI： 10.1017/S0950268815000023

Source DB:  PubMed          Journal:  Epidemiol Infect        ISSN： 0950-2688            Impact factor:   4.434


  14 in total

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Journal:  N Engl J Med       Date:  2005-12-01       Impact factor: 91.245

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10.  Epidemic Clostridium difficile ribotype 027 in Chile.

Authors:  Cristian Hernández-Rocha; Jonathan Barra-Carrasco; Marjorie Pizarro-Guajardo; Patricio Ibáñez; Susan M Bueno; Mahfuzur R Sarker; Ana María Guzman; Manuel Alvarez-Lobos; Daniel Paredes-Sabja
Journal:  Emerg Infect Dis       Date:  2012-08       Impact factor: 6.883
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9.  Comparative Genome Analysis and Global Phylogeny of the Toxin Variant Clostridium difficile PCR Ribotype 017 Reveals the Evolution of Two Independent Sublineages.

Authors:  M D Cairns; M D Preston; C L Hall; D N Gerding; P M Hawkey; H Kato; H Kim; E J Kuijper; T D Lawley; H Pituch; S Reid; B Kullin; T V Riley; K Solomon; P J Tsai; J S Weese; R A Stabler; B W Wren
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10.  Comprehensive evaluation of chemiluminescent immunoassays for the laboratory diagnosis of Clostridium difficile infection.

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