Literature DB >> 25687221

Calcium supplements controversy in osteoporosis: a physiological mechanism supporting cardiovascular adverse effects.

Karolina Paziana1, Michael Pazianas.   

Abstract

Recently, administration of calcium supplements for the prevention and treatment of osteoporosis has become a highly controversial issue. The findings of epidemiological studies are not necessarily supportive of the practice and are also open to different interpretations. In this article, we attempt to broaden the discussion and provide evidence that calcium supplementation may fail to compensate for renal calcium loss, and also that the resultant increased calcium load in the circulation could lead to extraskeletal deposition, including in the coronary arteries.

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Year:  2015        PMID： 25687221     DOI： 10.1007/s12020-015-0550-9

Source DB:  PubMed          Journal:  Endocrine        ISSN： 1355-008X            Impact factor:   3.633


  9 in total

1.  Calcium risk-benefit updated--new WHI analyses.

Authors:  Ian R Reid; Mark J Bolland
Journal:  Maturitas       Date:  2013-10-16       Impact factor: 4.342

2.  The effects of the menopause on calcitriol and parathyroid hormone: responses to a low dietary calcium stress test.

Authors:  R L Prince; I Dick; P Garcia-Webb; R W Retallack
Journal:  J Clin Endocrinol Metab       Date:  1990-04       Impact factor: 5.958

3.  A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women.

Authors:  B Dawson-Hughes; G E Dallal; E A Krall; L Sadowski; N Sahyoun; S Tannenbaum
Journal:  N Engl J Med       Date:  1990-09-27       Impact factor: 91.245

4.  Prevalence of renal impairment among osteoporotic women in the USA, NHANES 2005-2008: is treatment with bisphosphonates an option?

Authors:  R Lubwama; A Nguyen; A Modi; D Chirovsky; C Diana; P D Miller
Journal:  Osteoporos Int       Date:  2014-02-28       Impact factor: 4.507

5.  Increased interleukin-6 production by murine bone marrow and bone cells after estrogen withdrawal.

Authors:  G Passeri; G Girasole; R L Jilka; S C Manolagas
Journal:  Endocrinology       Date:  1993-08       Impact factor: 4.736

6.  Calcium and vitamin D intake maintained from preovariectomy independently affect calcium metabolism and bone properties in Sprague Dawley rats.

Authors:  C Y Park; W H Lee; J C Fleet; M R Allen; G P McCabe; D M Walsh; C M Weaver
Journal:  Osteoporos Int       Date:  2014-04-17       Impact factor: 4.507

Review 7.  Pathogenesis of age-related bone loss in humans.

Authors:  Sundeep Khosla
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-08-24       Impact factor: 6.053

Review 8.  Renal bone disease: a new conceptual framework for the interpretation of bone histomorphometry.

Authors:  A Michael Parfitt
Journal:  Curr Opin Nephrol Hypertens       Date:  2003-07       Impact factor: 2.894

9.  Mechanism of renal calcium conservation with estrogen replacement therapy in women in early postmenopause--a clinical research center study.

Authors:  W R McKane; S Khosla; M F Burritt; P C Kao; D M Wilson; S J Ory; B L Riggs
Journal:  J Clin Endocrinol Metab       Date:  1995-12       Impact factor: 5.958
  9 in total
  2 in total

Review 1.  Calcium supplementation and cardiovascular risk: A rising concern.

Authors:  Aurel T Tankeu; Valirie Ndip Agbor; Jean Jacques Noubiap
Journal:  J Clin Hypertens (Greenwich)       Date:  2017-05-02       Impact factor: 3.738

2.  Calcium fortification or supplementation in postmenopausal females: Recent controversy.

Authors:  Neelam Aggarwal; Sudhaa Sharma
Journal:  J Midlife Health       Date:  2016 Apr-Jun
  2 in total

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