Literature DB >> 25686674

The pathological role and prognostic impact of miR-181 in acute myeloid leukemia.

Hengyou Weng1, Kumar Lal2, Frank F Yang3, Jianjun Chen4.   

Abstract

In addition to genetic abnormalities, such as chromosomal translocations and somatic mutations that have been widely acknowledged in the leukemogenesis of acute myeloid leukemia (AML), epigenetic modifications also play a vital role in this process. MicroRNA (miRNA) regulation is emerging as a new layer of epigenetic regulation besides DNA methylation and histone modifications. Among the miRNAs first identified to be specifically expressed in hematopoietic cells, the miR-181 family has been implicated in regulating the differentiation of B cells, T cells, and natural killer cells during normal hematopoiesis, and has been linked tightly to the pathogenesis and prognosis of AML. Accumulating evidence indicates that miR-181 acts as a tumor suppressor in the pathogenesis of AML and exhibits a significant impact on the survival of patients with AML. Herein, we review the role of miR-181 as a diagnostic marker and prognostic predictor in AML, and discuss the potential use of miR-181 as a therapeutic target for AML.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Acute myeloid leukemia; diagnostic marker; miR-181; prognostic predictor; tumor suppressor

Mesh：

Substances：

Year:  2015        PMID： 25686674      PMCID： PMC4466067          DOI： 10.1016/j.cancergen.2014.12.006

Source DB:  PubMed          Journal:  Cancer Genet


  43 in total

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Review 3.  Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?

Authors:  Krzysztof Mrózek; Guido Marcucci; Peter Paschka; Susan P Whitman; Clara D Bloomfield
Journal:  Blood       Date:  2006-09-07       Impact factor: 22.113

Review 4.  The role of mutations in epigenetic regulators in myeloid malignancies.

Authors:  Alan H Shih; Omar Abdel-Wahab; Jay P Patel; Ross L Levine
Journal:  Nat Rev Cancer       Date:  2012-08-17       Impact factor: 60.716

5.  Cutting edge: microRNA-181 promotes human NK cell development by regulating Notch signaling.

Authors:  Frank Cichocki; Martin Felices; Valarie McCullar; Steven R Presnell; Ahmad Al-Attar; Charles T Lutz; Jeffrey S Miller
Journal:  J Immunol       Date:  2011-11-14       Impact factor: 5.422

6.  MicroRNAs modulate hematopoietic lineage differentiation.

Authors:  Chang-Zheng Chen; Ling Li; Harvey F Lodish; David P Bartel
Journal:  Science       Date:  2003-12-04       Impact factor: 47.728

7.  MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family.

Authors:  L J Beverly; H E Varmus
Journal:  Oncogene       Date:  2009-01-12       Impact factor: 9.867

8.  MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia.

Authors:  Ramiro Garzon; Stefano Volinia; Chang-Gong Liu; Cecilia Fernandez-Cymering; Tiziana Palumbo; Flavia Pichiorri; Muller Fabbri; Kevin Coombes; Hansjuerg Alder; Tatsuya Nakamura; Neal Flomenberg; Guido Marcucci; George A Calin; Steven M Kornblau; Hagop Kantarjian; Clara D Bloomfield; Michael Andreeff; Carlo M Croce
Journal:  Blood       Date:  2008-01-10       Impact factor: 22.113

9.  MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia.

Authors:  Shuangli Mi; Jun Lu; Miao Sun; Zejuan Li; Hao Zhang; Mary Beth Neilly; Yungui Wang; Zhijian Qian; Jie Jin; Yanming Zhang; Stefan K Bohlander; Michelle M Le Beau; Richard A Larson; Todd R Golub; Janet D Rowley; Jianjun Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-04       Impact factor: 11.205

10.  MicroRNA miR-181a correlates with morphological sub-class of acute myeloid leukaemia and the expression of its target genes in global genome-wide analysis.

Authors:  S Debernardi; S Skoulakis; G Molloy; T Chaplin; A Dixon-McIver; B D Young
Journal:  Leukemia       Date:  2007-03-01       Impact factor: 11.528
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  30 in total

1.  MicroRNAs and tRNA-derived fragments predict the transformation of myelodysplastic syndromes to acute myeloid leukemia.

Authors:  Yan Guo; Stephen A Strickland; Sanjay Mohan; Shaoying Li; Amma Bosompem; Kasey C Vickers; Shilin Zhao; Quanhu Sheng; Annette S Kim
Journal:  Leuk Lymphoma       Date:  2017-01-13

2.  Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.

Authors:  Nikolas Herold; Sean G Rudd; Linda Ljungblad; Kumar Sanjiv; Ida Hed Myrberg; Cynthia B J Paulin; Yaser Heshmati; Anna Hagenkort; Juliane Kutzner; Brent D G Page; José M Calderón-Montaño; Olga Loseva; Ann-Sofie Jemth; Lorenzo Bulli; Hanna Axelsson; Bianca Tesi; Nicholas C K Valerie; Andreas Höglund; Julia Bladh; Elisée Wiita; Mikael Sundin; Michael Uhlin; Georgios Rassidakis; Mats Heyman; Katja Pokrovskaja Tamm; Ulrika Warpman-Berglund; Julian Walfridsson; Sören Lehmann; Dan Grandér; Thomas Lundbäck; Per Kogner; Jan-Inge Henter; Thomas Helleday; Torsten Schaller
Journal:  Nat Med       Date:  2017-01-09       Impact factor: 53.440

3.  MicroRNA-181 contributes to downregulation of SAMHD1 expression in CD4+ T-cells derived from Sèzary syndrome patients.

Authors:  Rebecca Kohnken; Karthik M Kodigepalli; Anjali Mishra; Pierluigi Porcu; Li Wu
Journal:  Leuk Res       Date:  2016-11-17       Impact factor: 3.156

4.  MicroRNA-181 inhibits the proliferation, drug sensitivity and invasion of human glioma cells by targeting Selenoprotein K (SELK).

Authors:  Chun-Hua Xu; Li-Min Xiao; Er-Ming Zeng; Li-Ke Chen; Su-Yue Zheng; Dong-Hai Li; Yue Liu
Journal:  Am J Transl Res       Date:  2019-10-15       Impact factor: 4.060

5.  The miR-181 family regulates colonic inflammation through its activity in the intestinal epithelium.

Authors:  Monica T Jimenez; Megan L Clark; Jasmine M Wright; Michaël F Michieletto; Suying Liu; Isabel Erickson; Lenka Dohnalova; Giulia T Uhr; John Tello-Cajiao; Leonel Joannas; Adam Williams; Nicola Gagliani; Meenakshi Bewtra; Vesselin T Tomov; Christoph A Thaiss; Jorge Henao-Mejia
Journal:  J Exp Med       Date:  2022-09-08       Impact factor: 17.579

6.  miR-181a Promotes Multiple Protumorigenic Functions by Targeting TGFβR3.

Authors:  Vida Chitsazzadeh; Tran N Nguyen; Alvaro de Mingo Pulido; Bruna B Bittencourt; Lili Du; Charles H Adelmann; Ivannie Ortiz Rivera; Kimberly A Nguyen; Leah D Guerra; Andrew Davis; Marco Napoli; Wencai Ma; Richard Eric Davis; Kimal Rajapakshe; Cristian Coarfa; Elsa R Flores; Kenneth Y Tsai
Journal:  J Invest Dermatol       Date:  2021-12-08       Impact factor: 7.590

7.  microRNA-181a downregulates deptor for TGFβ-induced glomerular mesangial cell hypertrophy and matrix protein expression.

Authors:  Soumya Maity; Amit Bera; Nandini Ghosh-Choudhury; Falguni Das; Balakuntalam S Kasinath; Goutam Ghosh Choudhury
Journal:  Exp Cell Res       Date:  2018-02-01       Impact factor: 3.905

8.  Aberrant Expression of the miR-181b/miR-222 after Hematopoietic Stem Cell Transplantation in Patients with Acute Myeloid Leukemia.

Authors:  Mahdiyar Iravani Saadi; Nargess Arandi; Ramin Yaghobi; Negar Azarpira; Bita Geramizadeh; Mani Ramzi
Journal:  Indian J Hematol Blood Transfus       Date:  2019-01-21       Impact factor: 0.900

9.  Low expression of microRNA-204 (miR-204) is associated with poor clinical outcome of acute myeloid leukemia (AML) patients.

Authors:  Aleksandra Butrym; Justyna Rybka; Dagmara Baczyńska; Andrzej Tukiendorf; Kazimierz Kuliczkowski; Grzegorz Mazur
Journal:  J Exp Clin Cancer Res       Date:  2015-07-01

10.  Metformin-induced suppression of Nemo-like kinase improves erythropoiesis in preclinical models of Diamond-Blackfan anemia through induction of miR-26a.

Authors:  Mark C Wilkes; Kavitha Siva; Gianluca Varetti; Jacqueline Mercado; Ethan P Wentworth; Cristina A Perez; Mallika Saxena; Sharon Kam; Simryn Kapur; Jun Chen; Anu Narla; Bert Glader; Shou Lin; Manuel Serrano; Johan Flygare; Kathleen M Sakamoto
Journal:  Exp Hematol       Date:  2020-09-12       Impact factor: 3.084
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