Wen Peng1, Zhenyu Peng1, Xiangping Chai2, Qingyi Zhu3, Guifang Yang1, Qin Zhao1, Shenghua Zhou3. 1. Department of Emergency, Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan 410011, China. 2. Department of Emergency, Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan 410011, China. Electronic address: laochaicn@aliyun.com. 3. Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha, China.
Abstract
OBJECTIVE: The purpose of this study was to identify biological markers for early diagnosis of acute aortic dissection (AAD). METHODS: 76 patients presented to the emergency room with acute chest pain within 6 h of occurrence were recruited for this study, and AAD diagnosed by aortic CTA. Biomarkers were measured by ELISA. ROC curve and Pearson correlation analysis were used to evaluate the sensitivity and specificity to diagnosis of AAD. RESULTS: The serum levels of α-SMA, smMHC, sELAF, PC1 and D-dimer were significantly higher in AAD patients than in other groups (P < 0.05). Significant correlations between smMHC, sELAF, PC1, and D-dimer level were observed in AAD. Any combination of two markers showed good sensitivity (94.29%) and specificity (85.37%). CONCLUSION: smMHC, sELAF, PC1, or D-dimer alone is a biomarker for early diagnosis of AAD, but the combination of these markers has significantly higher diagnostic value.
OBJECTIVE: The purpose of this study was to identify biological markers for early diagnosis of acute aortic dissection (AAD). METHODS: 76 patients presented to the emergency room with acute chest pain within 6 h of occurrence were recruited for this study, and AAD diagnosed by aortic CTA. Biomarkers were measured by ELISA. ROC curve and Pearson correlation analysis were used to evaluate the sensitivity and specificity to diagnosis of AAD. RESULTS: The serum levels of α-SMA, smMHC, sELAF, PC1 and D-dimer were significantly higher in AAD patients than in other groups (P < 0.05). Significant correlations between smMHC, sELAF, PC1, and D-dimer level were observed in AAD. Any combination of two markers showed good sensitivity (94.29%) and specificity (85.37%). CONCLUSION:smMHC, sELAF, PC1, or D-dimer alone is a biomarker for early diagnosis of AAD, but the combination of these markers has significantly higher diagnostic value.
Authors: Rosina De Cario; Marco Giannini; Giulia Cassioli; Ada Kura; Anna Maria Gori; Rossella Marcucci; Stefano Nistri; Guglielmina Pepe; Betti Giusti; Elena Sticchi Journal: Diagnostics (Basel) Date: 2022-07-22
Authors: Evaldas Girdauskas; Niklas Neumann; Johannes Petersen; Tatiana Sequeira-Gross; Shiho Naito; Maria von Stumm; Yskert von Kodolitsch; Hermann Reichenspurner; Tanja Zeller Journal: J Clin Med Date: 2020-01-19 Impact factor: 4.241