Concetta Rafaniello1, Vincenzo Arcoraci2, Carmen Ferrajolo1, Liberata Sportiello1, Maria Giuseppa Sullo1, Francesco Giorgianni2, Gianluca Trifirò2, Michele Tari3, Achille P Caputi2, Francesco Rossi1, Katherine Esposito4, Dario Giugliano5, Annalisa Capuano6. 1. Regional Centre of Pharmacosurveillance and Pharmacoepidemiology, Department of Experimental Medicine, Second University of Naples, via de Crecchio 7, 80138 Naples, Italy. 2. Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria-Gazzi, 98125 Messina, Italy. 3. Caserta-1 Local Health Service, Caserta, Italy. 4. Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Naples, Italy. 5. Department of Medical, Surgical, Neurological, Metabolic Sciences, and Geriatrics, Second University of Naples, Naples, Italy. 6. Regional Centre of Pharmacosurveillance and Pharmacoepidemiology, Department of Experimental Medicine, Second University of Naples, via de Crecchio 7, 80138 Naples, Italy. Electronic address: annalisa.capuano@unina2.it.
Abstract
OBJECTIVE: To assess the prescribing pattern of antidiabetic drugs (AD) in a general practice of Southern Italy from 2009 to 2012, with focus on behaviour prescribing changes. METHODS: This retrospective, drug utilization study was conducted using administrative databases of the Local Health Unit of Caserta (Southern Italy) including about 1 million citizens. The standardized prevalence of AD use was calculated within each study year. A sample cohort of 78,789 subjects with at least one prescription of AD was identified during the study period. RESULTS: There was an overall increase of the proportion of the patients treated with monotherapy, which was significant for insulin monotherapy (from 11.2 to 14.6%, p<0.001). The proportion of patients treated with metformin remained stable (from 68.3% to 67.8%, p=0.076), while those receiving sulfonylurea dropped from 18.4% to 12.5% (p<0.001); GLP-1 analogues and DPP-4 inhibitors showed the greatest increase (from 1.2% to 6.6%, p<0.001). In the whole sample of 25,148 new AD users, metformin was the most commonly prescribed drug in monotherapy (41.9%), while insulin ranked second (13.3%). CONCLUSION: This study shows a rising trend of AD monotherapy, with sulfonylureas and incretins showing the more negative and positive trend, respectively.
OBJECTIVE: To assess the prescribing pattern of antidiabetic drugs (AD) in a general practice of Southern Italy from 2009 to 2012, with focus on behaviour prescribing changes. METHODS: This retrospective, drug utilization study was conducted using administrative databases of the Local Health Unit of Caserta (Southern Italy) including about 1 million citizens. The standardized prevalence of AD use was calculated within each study year. A sample cohort of 78,789 subjects with at least one prescription of AD was identified during the study period. RESULTS: There was an overall increase of the proportion of the patients treated with monotherapy, which was significant for insulin monotherapy (from 11.2 to 14.6%, p<0.001). The proportion of patients treated with metformin remained stable (from 68.3% to 67.8%, p=0.076), while those receiving sulfonylurea dropped from 18.4% to 12.5% (p<0.001); GLP-1 analogues and DPP-4 inhibitors showed the greatest increase (from 1.2% to 6.6%, p<0.001). In the whole sample of 25,148 new AD users, metformin was the most commonly prescribed drug in monotherapy (41.9%), while insulin ranked second (13.3%). CONCLUSION: This study shows a rising trend of AD monotherapy, with sulfonylureas and incretins showing the more negative and positive trend, respectively.
Authors: Giuseppe Roberto; Anna Girardi; Francesco Barone-Adesi; Alessandro Pecere; Valentina Ientile; Claudia Bartolini; Roberto Da Cas; Stefania Spila-Alegiani; Carmen Ferrajolo; Paolo Francesconi; Gianluca Trifirò; Elisabetta Poluzzi; Fabio Baccetti; Rosa Gini Journal: Front Pharmacol Date: 2022-05-30 Impact factor: 5.988
Authors: Alexander J Whittam; Zeshaan N Maan; Dominik Duscher; Janos A Barrera; Michael S Hu; Lauren H Fischer; Sacha Khong; Sun Hyung Kwon; Victor W Wong; Graham G Walmsley; Ferdinando Giacco; Michael Januszyk; Michael Brownlee; Michael T Longaker; Geoffrey C Gurtner Journal: Transl Res Date: 2018-11-02 Impact factor: 7.012
Authors: Martin Busch; Jennifer Nadal; Matthias Schmid; Katharina Paul; Stephanie Titze; Silvia Hübner; Anna Köttgen; Ulla T Schultheiss; Seema Baid-Agrawal; Johan Lorenzen; Georg Schlieper; Claudia Sommerer; Vera Krane; Robert Hilge; Jan T Kielstein; Florian Kronenberg; Christoph Wanner; Kai-Uwe Eckardt; Gunter Wolf Journal: BMC Nephrol Date: 2016-06-11 Impact factor: 2.388