Literature DB >> 25685998

Heat-shock protein 90 inhibitors: will they ever succeed as chemotherapeutics?

Yao Wang1, Shelli R McAlpine.   

Abstract

Keywords:  C-terminal; Hsp90 inhibitors; Hsp90 modulators; heat-shock protein; heat-shock protein 90 chaperones; heat-shock response; stress

Mesh：

Substances：

Year:  2015        PMID： 25685998     DOI： 10.4155/fmc.14.154

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


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  9 in total

Review 1.  Strategies to Enhance Radiosensitivity to Heavy Ion Radiation Therapy.

Authors:  Younghyun Lee; Ryuichi Okayasu
Journal:  Int J Part Ther       Date:  2018-09-21

2.  The HSP90 Inhibitor, 17-AAG, Influences the Activation and Proliferation of T Lymphocytes via AKT/GSK3β Signaling in MRL/lpr Mice.

Authors:  Liang-Jian Hong; Ai-Jun Chen; Feng-Zeng Li; Ke-Jun Chen; Sheng Fang
Journal:  Drug Des Devel Ther       Date:  2020-10-29       Impact factor: 4.162

3.  Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization.

Authors:  Sanil Bhatia; Lukas Spanier; David Bickel; Niklas Dienstbier; Vitalij Woloschin; Melina Vogt; Henrik Pols; Beate Lungerich; Jens Reiners; Narges Aghaallaei; Daniela Diedrich; Benedikt Frieg; Julian Schliehe-Diecks; Bertan Bopp; Franziska Lang; Mohanraj Gopalswamy; Jennifer Loschwitz; Baubak Bajohgli; Julia Skokowa; Arndt Borkhardt; Julia Hauer; Finn K Hansen; Sander H J Smits; Joachim Jose; Holger Gohlke; Thomas Kurz
Journal:  ACS Cent Sci       Date:  2022-04-27       Impact factor: 18.728

4.  Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response.

Authors:  Sanil Bhatia; Daniela Diedrich; Benedikt Frieg; Heinz Ahlert; Stefan Stein; Bertan Bopp; Franziska Lang; Tao Zang; Tobias Kröger; Thomas Ernst; Gesine Kögler; Andreas Krieg; Steffen Lüdeke; Hana Kunkel; Ana J Rodrigues Moita; Matthias U Kassack; Viktoria Marquardt; Friederike V Opitz; Marina Oldenburg; Marc Remke; Florian Babor; Manuel Grez; Andreas Hochhaus; Arndt Borkhardt; Georg Groth; Luitgard Nagel-Steger; Joachim Jose; Thomas Kurz; Holger Gohlke; Finn K Hansen; Julia Hauer
Journal:  Blood       Date:  2018-05-03       Impact factor: 22.113

5.  Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer.

Authors:  Anne-Marie Ray; Nilshad Salim; Mckayla Stevens; Siddhi Chitre; Sanofar Abdeen; Alex Washburn; Jared Sivinski; Heather M O'Hagan; Eli Chapman; Steven M Johnson
Journal:  Bioorg Med Chem       Date:  2021-04-19       Impact factor: 3.461

6.  Hsp90 Is a Novel Target Molecule of CDDO-Me in Inhibiting Proliferation of Ovarian Cancer Cells.

Authors:  Dong-Jun Qin; Cai-Xia Tang; Li Yang; Hu Lei; Wei Wei; Ying-Ying Wang; Chun-Min Ma; Feng-Hou Gao; Han-Zhang Xu; Ying-Li Wu
Journal:  PLoS One       Date:  2015-07-02       Impact factor: 3.240

7.  X66, a novel N-terminal heat shock protein 90 inhibitor, exerts antitumor effects without induction of heat shock response.

Authors:  Zhixin Zhao; Jianming Zhu; Haitian Quan; Guimin Wang; Bo Li; Weiliang Zhu; Chengying Xie; Liguang Lou
Journal:  Oncotarget       Date:  2016-05-17

8.  17-Aminogeldanamycin selectively diminishes IRE1α-XBP1s pathway activity and cooperatively induces apoptosis with MEK1/2 and BRAFV600E inhibitors in melanoma cells of different genetic subtypes.

Authors:  Aleksandra Mielczarek-Lewandowska; Malgorzata Sztiller-Sikorska; Marta Osrodek; Malgorzata Czyz; Mariusz L Hartman
Journal:  Apoptosis       Date:  2019-08       Impact factor: 4.677

9.  Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary Renal Cell Carcinoma.

Authors:  Roma Pahwa; Janhavi Dubhashi; Anand Singh; Parthav Jailwala; Alexei Lobanov; Craig J Thomas; Michele Ceribelli; Kelli Wilson; Christopher J Ricketts; Cathy D Vocke; Catherine Wells; Donald P Bottaro; W Marston Linehan; Len Neckers; Ramaprasad Srinivasan
Journal:  J Exp Clin Cancer Res       Date:  2022-06-27
  9 in total

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