AIM: To investigate the mechanisms by which Csk-binding protein (CBP) inhibits tumor progression in esophageal carcinoma. METHODS: A CBP overexpressing esophageal carcinoma cell line (TE-1) was established. The growth, invasion, and migration of CBP-TE-1 cells, as well as the expression of Src were then determined and compared with those in normal TE-1 cells. RESULTS: The expression of Src was decreased by the overexpression of CBP in TE-1 cells. The growth, invasion, and migration of TE-1 cells were decreased by the overexpression of CBP. CONCLUSION: This study indicates that CBP may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src. CBP may be a potential tumor suppressor and targeting the CBP gene may be an alternative strategy for the development of therapies for esophageal carcinoma.
AIM: To investigate the mechanisms by which Csk-binding protein (CBP) inhibits tumor progression in esophageal carcinoma. METHODS: A CBP overexpressing esophageal carcinoma cell line (TE-1) was established. The growth, invasion, and migration of CBP-TE-1 cells, as well as the expression of Src were then determined and compared with those in normal TE-1 cells. RESULTS: The expression of Src was decreased by the overexpression of CBP in TE-1 cells. The growth, invasion, and migration of TE-1 cells were decreased by the overexpression of CBP. CONCLUSION: This study indicates that CBP may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src. CBP may be a potential tumor suppressor and targeting the CBP gene may be an alternative strategy for the development of therapies for esophageal carcinoma.
Authors: Sebastian Michels; Marcel Trautmann; Elisabeth Sievers; Dagmar Kindler; Sebastian Huss; Marcus Renner; Nicolaus Friedrichs; Jutta Kirfel; Susanne Steiner; Elmar Endl; Peter Wurst; Lukas Heukamp; Roland Penzel; Olle Larsson; Akira Kawai; Shinya Tanaka; Hiroshi Sonobe; Peter Schirmacher; Gunhild Mechtersheimer; Eva Wardelmann; Reinhard Büttner; Wolfgang Hartmann Journal: Cancer Res Date: 2013-04-11 Impact factor: 12.701
Authors: Sarah E Seton-Rogers; Yu Lu; Lisa M Hines; Malvika Koundinya; Joshua LaBaer; Senthil K Muthuswamy; Joan S Brugge Journal: Proc Natl Acad Sci U S A Date: 2004-01-22 Impact factor: 11.205
Authors: Gary A Clawson; Gail L Matters; Ping Xin; Christopher McGovern; Eric Wafula; Claude dePamphilis; Morgan Meckley; Joyce Wong; Luke Stewart; Christopher D'Jamoos; Naomi Altman; Yuka Imamura Kawasawa; Zhen Du; Loren Honaas; Thomas Abraham Journal: PLoS One Date: 2017-09-28 Impact factor: 3.240