| Literature DB >> 25684444 |
Sarah Abou-Shehada1, Matthew C Teasdale, Steven D Bull, Charles E Wade, Jonathan M J Williams.
Abstract
A clean, mild and sustainable method for the functionalization of pyridines and their analogues is reported. A zinc-based Lewis acid is used to activate pyridine and its analogues towards nucleophilic aromatic substitution, conjugate addition, and cyclization reactions by binding to the nitrogen on the pyridine ring and activating the pyridine ring core towards further functionalization.Entities:
Keywords: SNAr; amination; conjugate addition; lewis acid; pyridine
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Year: 2015 PMID： 25684444 DOI： 10.1002/cssc.201403154
Source DB: PubMed Journal: ChemSusChem ISSN： 1864-5631 Impact factor: 8.928