Literature DB >> 25683897

IGFBP-2/PTEN: A critical interaction for tumours and for general physiology?

Li Zeng1, Claire M Perks2, Jeff M P Holly1.   

Abstract

IGFBP-2 is an important modulator of IGF availability and activity. It is the second most abundant of the IGFBPs in the circulation and its levels are increased in a variety of tumours and associated with progression and poor prognosis. PTEN is a phosphatase that returns the PI3K/AKT/mTOR pathway to its inactivated state and is therefore a critical modulator of one of the main intracellular signalling pathways activated by the IGFs. Recent evidence has indicated that IGFBP-2 regulates PTEN in a variety of normal and malignant cell types. This review summarises the recent evidence that these extracellular and intracellular modulators are linked to provide a synchronous system for cell regulation with coordinated control of both the 'accelerator' and the 'brake'.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Feedback; IGF-II; IGFBP-2; PI3K; PTEN

Mesh：

Substances：

Year:  2015        PMID： 25683897     DOI： 10.1016/j.ghir.2015.01.003

Source DB:  PubMed          Journal:  Growth Horm IGF Res        ISSN： 1096-6374            Impact factor:   2.372


  6 in total

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2.  Hyperglycemia Promotes TMPRSS2-ERG Gene Fusion in Prostate Cancer Cells via Upregulating Insulin-Like Growth Factor-Binding Protein-2.

Authors:  Jeff M P Holly; Jessica Broadhurst; Rehanna Mansor; Amit Bahl; Claire M Perks
Journal:  Front Endocrinol (Lausanne)       Date:  2017-11-06       Impact factor: 5.555

3.  Prognostic relevance and performance characteristics of serum IGFBP-2 and PAPP-A in women with breast cancer: a long-term Danish cohort study.

Authors:  Ulrick Espelund; Andrew G Renehan; Søren Cold; Claus Oxvig; Lee Lancashire; Zhenqiang Su; Allan Flyvbjerg; Jan Frystyk
Journal:  Cancer Med       Date:  2018-05-03       Impact factor: 4.452

4.  Short-Term Diet Induced Changes in the Central and Circulating IGF Systems Are Sex Specific.

Authors:  Santiago Guerra-Cantera; Laura M Frago; Francisca Díaz; Purificacion Ros; Maria Jiménez-Hernaiz; Alejandra Freire-Regatillo; Vicente Barrios; Jesús Argente; Julie A Chowen
Journal:  Front Endocrinol (Lausanne)       Date:  2020-08-11       Impact factor: 5.555

Review 5.  Insulin-like growth factors: Ligands, binding proteins, and receptors.

Authors:  Derek LeRoith; Jeff M P Holly; Briony E Forbes
Journal:  Mol Metab       Date:  2021-05-04       Impact factor: 7.422

6.  Anticancer properties of dried-pericarp water extracts of Camellia japonica L. fermented with Aspergillus oryzae through regulation of IGFBP-2/mTOR pathway.

Authors:  Eugene Cho; Jin Kim; Da Hye Jeong; Hyoun Woo Kim
Journal:  Sci Rep       Date:  2021-11-02       Impact factor: 4.379
  6 in total

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