BACKGROUND: Canine atopic dermatitis (AD) is a common, genetically predisposed, inflammatory and pruritic skin disease. The pathogenesis of canine AD is incompletely understood. OBJECTIVES: The aim of this review is to provide an in-depth update on the involvement of skin barrier and host-microbiome interaction in the pathogenesis of canine AD. METHODS: Online citation databases and abstracts from international meetings were searched for publications related to skin barrier and host-microbiome interaction (e.g. bacteria, yeast, antimicrobial peptides). RESULTS: A total of 126 publications were identified. This review article focuses on epidermal barrier dysfunction and the interaction between cutaneous microbes (bacteria and yeasts) and the host (antimicrobial peptides). Epidemiological updates on the presence of pathogenic organisms and canine AD are also provided. CONCLUSIONS AND CLINICAL IMPORTANCE: Major advances have been made in the investigation of skin barrier dysfunction in canine AD, although many questions still remain. Skin barrier dysfunction and host-microbiome interactions are emerging as primary alterations in canine AD. Based on this review, it is clear that future studies focused on the development of drugs able to restore the skin barrier and increase the natural defences against pathogenic organisms are needed.
BACKGROUND:Canineatopic dermatitis (AD) is a common, genetically predisposed, inflammatory and pruritic skin disease. The pathogenesis of canineAD is incompletely understood. OBJECTIVES: The aim of this review is to provide an in-depth update on the involvement of skin barrier and host-microbiome interaction in the pathogenesis of canineAD. METHODS: Online citation databases and abstracts from international meetings were searched for publications related to skin barrier and host-microbiome interaction (e.g. bacteria, yeast, antimicrobial peptides). RESULTS: A total of 126 publications were identified. This review article focuses on epidermal barrier dysfunction and the interaction between cutaneous microbes (bacteria and yeasts) and the host (antimicrobial peptides). Epidemiological updates on the presence of pathogenic organisms and canineAD are also provided. CONCLUSIONS AND CLINICAL IMPORTANCE: Major advances have been made in the investigation of skin barrier dysfunction in canineAD, although many questions still remain. Skin barrier dysfunction and host-microbiome interactions are emerging as primary alterations in canineAD. Based on this review, it is clear that future studies focused on the development of drugs able to restore the skin barrier and increase the natural defences against pathogenic organisms are needed.
Authors: Charles W Bradley; Daniel O Morris; Shelley C Rankin; Christine L Cain; Ana M Misic; Timothy Houser; Elizabeth A Mauldin; Elizabeth A Grice Journal: J Invest Dermatol Date: 2016-02-06 Impact factor: 8.551
Authors: Gagandeep Kaur; Ana Ramirez; Chen Xie; David Clark; Charli Dong; Chad Maki; Thomas Ramos; Fari Izadyar; Sandy Oliver Lopez Najera; Jerry Harb; Jijun Hao Journal: Vet Res Commun Date: 2021-10-29 Impact factor: 2.459
Authors: Giovanni Widmer; Lluís Ferrer; Claude Favrot; Judy Paps; Kevin Huynh; Thierry Olivry Journal: BMC Vet Res Date: 2018-02-23 Impact factor: 2.741
Authors: Robin Moore; Johanna Anturaniemi; Vidya Velagapudi; Jatin Nandania; Stella Maria Barrouin-Melo; Anna Hielm-Björkman Journal: Front Vet Sci Date: 2020-10-27