Baris Turkbey1, Robert F Hoyt2, Harsh K Agarwal3, Marcelino Bernardo4, Sandeep Sankineni5, Linda Johnson5, Kinzya B Grant5, Soroush Rais-Bahrami6, Hisataka Kobayashi5, Bradford J Wood7, Peter A Pinto8, Gary L Griffiths9, Peter L Choyke5. 1. Molecular Imaging Program, NCI, NIH, 10 Center Dr, MSC 1182 Bldg 10, Room B3B85, Bethesda, MD 20892-1088. Electronic address: turkbeyi@mail.nih.gov. 2. Laboratory of Animal Medicine and Surgery NHLBI, NIH, Bethesda, Maryland; Laboratory Animal Science Program, Leidos Biomedical Research Inc. (formerly SAIC-Frederick, Inc.), Frederick National Laboratory for Cancer Research, Frederick, Maryland. 3. Molecular Imaging Program, NCI, NIH, 10 Center Dr, MSC 1182 Bldg 10, Room B3B85, Bethesda, MD 20892-1088; Philips Research North America, Briarcliff Manor, New York. 4. Molecular Imaging Program, NCI, NIH, 10 Center Dr, MSC 1182 Bldg 10, Room B3B85, Bethesda, MD 20892-1088; Laboratory Animal Science Program, Leidos Biomedical Research Inc. (formerly SAIC-Frederick, Inc.), Frederick National Laboratory for Cancer Research, Frederick, Maryland. 5. Molecular Imaging Program, NCI, NIH, 10 Center Dr, MSC 1182 Bldg 10, Room B3B85, Bethesda, MD 20892-1088. 6. Urologic Oncology Branch, NCI, NIH, Bethesda, Maryland. 7. Center for Interventional Oncology, NCI and Radiology and Imaging Sciences, Clinical Center, NIH, Bethesda, Maryland. 8. Urologic Oncology Branch, NCI, NIH, Bethesda, Maryland; Center for Interventional Oncology, NCI and Radiology and Imaging Sciences, Clinical Center, NIH, Bethesda, Maryland. 9. Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research Inc. (formerly SAIC-Frederick, Inc.), Frederick National Laboratory for Cancer Research, Frederick, Maryland.
Abstract
RATIONALE AND OBJECTIVES: To determine if intraprostatic injection of gadofosveset trisodium mixed with human serum albumin (HSA) can identify sentinel lymph nodes (LNs) draining the prostate on magnetic resonance imaging (MRI) in a canine model. MATERIALS AND METHODS: Three male canines weighing between 25.7 and 41.3 kg were anesthetized, placed in a 3-T MRI, and a needle was placed transrectally into one side of the prostate using a commercially available intrarectal needle guide. Gadofosveset trisodium premixed with 10% HSA was then administered at doses ranging from 0.1 to 2.5 mL. T1W MRI was performed immediately after injection, and two readers evaluated images for visualization of LNs draining the prostate. RESULTS: Intraprostatic injection of 0.2 mL gadofosveset trisodium premixed with HSA identified the draining periprostatic LNs in all cases. Delayed images demonstrated upper echelon nodes in the pelvis and the abdomen. Higher volume injections resulted in excessive periprostatic extravasation, whereas lower volume injections resulted in suboptimal visualization of LNs. CONCLUSIONS: We demonstrate that gadofosveset trisodium (premixed with 10% HSA) injected intraprostatically at 0.2 mL visualized LNs draining the prostate. This approach can be readily adapted for clinical applications such as sentinel LN imaging in prostate cancer patients before surgery. Published by Elsevier Inc.
RATIONALE AND OBJECTIVES: To determine if intraprostatic injection of gadofosveset trisodium mixed with humanserum albumin (HSA) can identify sentinel lymph nodes (LNs) draining the prostate on magnetic resonance imaging (MRI) in a canine model. MATERIALS AND METHODS: Three male canines weighing between 25.7 and 41.3 kg were anesthetized, placed in a 3-T MRI, and a needle was placed transrectally into one side of the prostate using a commercially available intrarectal needle guide. Gadofosveset trisodium premixed with 10% HSA was then administered at doses ranging from 0.1 to 2.5 mL. T1W MRI was performed immediately after injection, and two readers evaluated images for visualization of LNs draining the prostate. RESULTS: Intraprostatic injection of 0.2 mL gadofosveset trisodium premixed with HSA identified the draining periprostatic LNs in all cases. Delayed images demonstrated upper echelon nodes in the pelvis and the abdomen. Higher volume injections resulted in excessive periprostatic extravasation, whereas lower volume injections resulted in suboptimal visualization of LNs. CONCLUSIONS: We demonstrate that gadofosveset trisodium (premixed with 10% HSA) injected intraprostatically at 0.2 mL visualized LNs draining the prostate. This approach can be readily adapted for clinical applications such as sentinel LN imaging in prostate cancerpatients before surgery. Published by Elsevier Inc.
Entities:
Keywords:
Gadofosveset trisodium; MRI; human serum albumin; lymph node
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