OBJECTIVE: To evaluate for the first time the longitudinal relationship between abdominal obesity and the onset of frailty. METHODS: Study based on results from two population-based cohorts, the Seniors-ENRICA, with 1801 individuals aged ≥60, and the Toledo Study for Healthy Ageing (TSHA), with 1289 participants ≥65 years. Incident frailty was assessed with the Fried criteria. RESULTS: During 3.5 years of follow-up, 125 individuals with incident frailty in Seniors-ENRICA and 162 in TSHA were identified. After adjustment for the main confounders, the pooled odds ratio (pooled OR) for general obesity and risk of frailty was 1.73 (95% confidence interval [CI]: 1.18-2.28). Abdominal obesity was also associated with frailty (pooled OR: 1.67; 95% CI: 1.09-2.25). Compared with individuals with BMI <25 kg/m(2) and no abdominal obesity, the risk of frailty was highest among individuals with concurrent general and abdominal obesity (pooled OR: 2.55; 95% CI: 1.23-3.86). General obesity was associated with increased risk of exhaustion (pooled OR: 1.66; 95% CI: 1.11-2.21), low physical activity (pooled OR: 1.57; 95% CI: 1.08-2.05), and weakness (pooled OR: 1.63; 95% CI: 1.12-2.05). For abdominal obesity, results were in the same direction, although they showed statistical significance only for weakness (OR: 1.46; 95% CI: 1.11-1.80). CONCLUSIONS: General and abdominal obesity are associated with incident frailty in the elderly.
OBJECTIVE: To evaluate for the first time the longitudinal relationship between abdominal obesity and the onset of frailty. METHODS: Study based on results from two population-based cohorts, the Seniors-ENRICA, with 1801 individuals aged ≥60, and the Toledo Study for Healthy Ageing (TSHA), with 1289 participants ≥65 years. Incident frailty was assessed with the Fried criteria. RESULTS: During 3.5 years of follow-up, 125 individuals with incident frailty in Seniors-ENRICA and 162 in TSHA were identified. After adjustment for the main confounders, the pooled odds ratio (pooled OR) for general obesity and risk of frailty was 1.73 (95% confidence interval [CI]: 1.18-2.28). Abdominal obesity was also associated with frailty (pooled OR: 1.67; 95% CI: 1.09-2.25). Compared with individuals with BMI <25 kg/m(2) and no abdominal obesity, the risk of frailty was highest among individuals with concurrent general and abdominal obesity (pooled OR: 2.55; 95% CI: 1.23-3.86). General obesity was associated with increased risk of exhaustion (pooled OR: 1.66; 95% CI: 1.11-2.21), low physical activity (pooled OR: 1.57; 95% CI: 1.08-2.05), and weakness (pooled OR: 1.63; 95% CI: 1.12-2.05). For abdominal obesity, results were in the same direction, although they showed statistical significance only for weakness (OR: 1.46; 95% CI: 1.11-1.80). CONCLUSIONS: General and abdominal obesity are associated with incident frailty in the elderly.
Authors: Samah Hayek; Todd M Gibson; Wendy M Leisenring; Jennifer L Guida; Maria Monica Gramatges; Philip J Lupo; Rebecca M Howell; Kevin C Oeffinger; Smita Bhatia; Kim Edelstein; Melissa M Hudson; Leslie L Robison; Paul C Nathan; Yutaka Yasui; Kevin R Krull; Gregory T Armstrong; Kirsten K Ness Journal: J Clin Oncol Date: 2019-12-04 Impact factor: 44.544
Authors: Michaela R Anderson; Nicholas A Kolaitis; Ying Gao; Jasleen Kukreja; John Greenland; Steven Hays; Paul Wolters; Jeff Golden; Joshua Diamond; Scott Palmer; Selim Arcasoy; Jayaram Udupa; Jason D Christie; David J Lederer; Jonathan P Singer Journal: Am J Transplant Date: 2019-07-24 Impact factor: 8.086
Authors: James S Andrews; Laura Trupin; Edward H Yelin; Catherine L Hough; Kenneth E Covinsky; Patricia P Katz Journal: Clin Rheumatol Date: 2017-01-23 Impact factor: 2.980
Authors: Aida Venado; Nicholas A Kolaitis; Chiung-Yu Huang; Ying Gao; David V Glidden; Allison Soong; Nicole Sutter; Patricia P Katz; John R Greenland; Daniel R Calabrese; Steven R Hays; Jeffrey A Golden; Rupal J Shah; Lorriana E Leard; Jasleen Kukreja; Tobias Deuse; Paul J Wolters; Kenneth Covinsky; Paul D Blanc; Jonathan P Singer Journal: Thorax Date: 2020-05-06 Impact factor: 9.139
Authors: Verónica Cabanas-Sánchez; Miguel A De la Cámara; Kabir P Sadarangani; Sara Higueras-Fresnillo; David Martinez-Gomez Journal: Int J Obes (Lond) Date: 2019-08-27 Impact factor: 5.095
Authors: Anna Pieczyńska; Ewa Zasadzka; Tomasz Trzmiel; Małgorzata Pyda; Mariola Pawlaczyk Journal: Int J Environ Res Public Health Date: 2021-05-24 Impact factor: 3.390