OBJECTIVE: To examine the prevalence of multimorbidity (≥2 chronic conditions) in severely obese patients and its associations with weight loss and health status over 2 years. METHODS: In a prospective cohort including 500 severely obese adults, self-reported prevalence of 20 chronic conditions was calculated at baseline and 2 years. Multivariable logistic regression models were fitted to test the covariate-adjusted associations between ≥5% weight reduction and reduction in multimorbidity and the association between health status (visual analogue scale [VAS]) and reduction in multimorbidity over 2 years. RESULTS: After 2 years, mean weight change was -12.9 ±18.7 kg, 53% had ≥5% weight reduction, mean change in VAS was 11.5 ± 21.2, and 53.5% had ≥10% increase in VAS. Multimorbidity was reported in 95.4% and 92.8% patients at baseline and 2 years, respectively. Weight loss (≥5%) over 2 years was associated with reduction in multimorbidity (adjusted OR = 1.7, 95% CI 1.1-2.7). Reduction in multimorbidity was associated with clinically important improvements (≥10% increase in VAS) in health status (adjusted OR = 2.5, 95% CI 1.6, 4.0). CONCLUSIONS: Multimorbidity is common in severely obese patients. Having ≥5% weight reduction over 2 years was associated with a reduction in multimorbidity, which was also associated with improvements in health status.
OBJECTIVE: To examine the prevalence of multimorbidity (≥2 chronic conditions) in severely obesepatients and its associations with weight loss and health status over 2 years. METHODS: In a prospective cohort including 500 severely obese adults, self-reported prevalence of 20 chronic conditions was calculated at baseline and 2 years. Multivariable logistic regression models were fitted to test the covariate-adjusted associations between ≥5% weight reduction and reduction in multimorbidity and the association between health status (visual analogue scale [VAS]) and reduction in multimorbidity over 2 years. RESULTS: After 2 years, mean weight change was -12.9 ±18.7 kg, 53% had ≥5% weight reduction, mean change in VAS was 11.5 ± 21.2, and 53.5% had ≥10% increase in VAS. Multimorbidity was reported in 95.4% and 92.8% patients at baseline and 2 years, respectively. Weight loss (≥5%) over 2 years was associated with reduction in multimorbidity (adjusted OR = 1.7, 95% CI 1.1-2.7). Reduction in multimorbidity was associated with clinically important improvements (≥10% increase in VAS) in health status (adjusted OR = 2.5, 95% CI 1.6, 4.0). CONCLUSIONS: Multimorbidity is common in severely obesepatients. Having ≥5% weight reduction over 2 years was associated with a reduction in multimorbidity, which was also associated with improvements in health status.
Authors: Louise H Dekker; Martin H de Borst; Laura M G Meems; Rudolf A de Boer; Stephan J L Bakker; Gerjan J Navis Journal: PLoS One Date: 2019-08-08 Impact factor: 3.240
Authors: Amber D Rochette; Mary Beth Spitznagel; Gladys Strain; Michael Devlin; Ross D Crosby; James E Mitchell; Anita Courcoulas; John Gunstad Journal: Obesity (Silver Spring) Date: 2016-05-26 Impact factor: 5.002
Authors: Carlene A Johnson Stoklossa; Sunita S Ghosh; Mary Forhan; Arya M Sharma; Tasuku Terada; Mario Siervo; Vickie E Baracos; Raj S Padwal; Pam A Hung; Michael B Sawyer; Yara Lm Maia; Carla M Prado Journal: Curr Dev Nutr Date: 2017-12-18