| Literature DB >> 25681817 |
Quan-Xia Lv1, Wenyue Wang2, Xing-Hong Li3, Lianlian Yu1, Yun Zhang2, Yuan Tian4.
Abstract
To Date, the knowledge on relationship between PCBs/PBDEs exposure and thyroid hormones (THs) levels during pregnancy still needs to be extended. Meanwhile, studies on congener-specific adipose-serum ratios for PCBs/PBDEs were limited. This study reports the levels of PCBs/PBDEs in serum-adipose tissue samples (n = 64) from expectant women living surrounding e-waste recycling sites in Wenling, China. Their concentrations varied from several to hundreds of ng g(-1) lipid. Maternal exposure to PCBs was associated with lower TSH during pregnancy, suggesting possible implication for maternal health and fetal development. The compound levels between the adipose tissue and matched serum samples were highly correlated (p < 0.001), generating a predicted adipose-serum partitioning relationship for individual PCB congener and PBDE congener. Molecular characteristics, such as Kow value, molecular weight and molecular volume, may play a key role in the variable partitioning of some compounds between serum and adipose tissue.Entities:
Keywords: Adipose/serum ratio; E-waste; PCBs and PBDEs; THs
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Year: 2015 PMID： 25681817 DOI： 10.1016/j.envpol.2015.02.008
Source DB: PubMed Journal: Environ Pollut ISSN： 0269-7491 Impact factor: 8.071