Mark Hamer1, Lee Smith2, Emmanuel Stamatakis3. 1. Physical Activity Research Group, Department of Epidemiology and Public Health, University College London, UK. Electronic address: m.hamer@ucl.ac.uk. 2. Physical Activity Research Group, Department of Epidemiology and Public Health, University College London, UK; Health Behaviour Research Centre, Department of Epidemiology and Public Health, University College London, UK. 3. Physical Activity Research Group, Department of Epidemiology and Public Health, University College London, UK; Prevention Research Collaboration, Sydney School of Public Health, University of Sydney, Australia; Charles Perkins Centre, University of Sydney, Australia; Exercise and Sports Science, Faculty of Health Sciences, University of Sydney, Australia.
Abstract
OBJECTIVE: Inflammatory processes are putative mechanisms underlying the detrimental health effects of sedentary behaviour but no long-term prospective data are available. We examined the longitudinal association between TV viewing, physical activity and inflammatory markers over a 4-year follow-up period. METHODS: Participants were 3612 men and women (mean age 64.1 ± 8.2 years) from the English Longitudinal Study of Ageing. Self-reported daily TV viewing was measured at baseline and 2 years follow up. Inflammatory markers (serum high-sensitivity C-reactive protein [CRP], white blood cell count [WBC], and fibrinogen) were measured at baseline (2008/09) and 4 years follow-up (2012/13). RESULTS: On average, participants viewed TV for 5.1 ± 4.0 h/d, and there was an increase of 1.9 h/wk TV viewing over 2 years. In linear models adjusted for covariates including physical activity, TV viewing was not associated with logeCRP at follow-up (B = 0.004, 95% CI, -0.001, 0.009, p = 0.09) but was associated with WBC (B = 0.018, 95% CI, 0.005, 0.031, p = 0.006), and fibrinogen (B = 0.004, 95% CI, 0.00, 0.008, p = 0.035). In contrast, physical activity was inversely associated with CRP (p = 0.047) and WBC (p = 0.026), but not fibrinogen (p = 0.22). An increase in TV viewing (of at least 1 h/d) was associated with higher concentrations of CRP (p = 0.015) and WBC (p = 0.05) at follow up after adjustment for covariates and baseline TV viewing. CONCLUSIONS: Physical activity and sedentary behaviour have contrasting associations with markers of low grade inflammation over 4 years of follow-up. These behaviours may be important in influencing the pro-inflammatory state seen with ageing.
OBJECTIVE: Inflammatory processes are putative mechanisms underlying the detrimental health effects of sedentary behaviour but no long-term prospective data are available. We examined the longitudinal association between TV viewing, physical activity and inflammatory markers over a 4-year follow-up period. METHODS: Participants were 3612 men and women (mean age 64.1 ± 8.2 years) from the English Longitudinal Study of Ageing. Self-reported daily TV viewing was measured at baseline and 2 years follow up. Inflammatory markers (serum high-sensitivity C-reactive protein [CRP], white blood cell count [WBC], and fibrinogen) were measured at baseline (2008/09) and 4 years follow-up (2012/13). RESULTS: On average, participants viewed TV for 5.1 ± 4.0 h/d, and there was an increase of 1.9 h/wk TV viewing over 2 years. In linear models adjusted for covariates including physical activity, TV viewing was not associated with logeCRP at follow-up (B = 0.004, 95% CI, -0.001, 0.009, p = 0.09) but was associated with WBC (B = 0.018, 95% CI, 0.005, 0.031, p = 0.006), and fibrinogen (B = 0.004, 95% CI, 0.00, 0.008, p = 0.035). In contrast, physical activity was inversely associated with CRP (p = 0.047) and WBC (p = 0.026), but not fibrinogen (p = 0.22). An increase in TV viewing (of at least 1 h/d) was associated with higher concentrations of CRP (p = 0.015) and WBC (p = 0.05) at follow up after adjustment for covariates and baseline TV viewing. CONCLUSIONS: Physical activity and sedentary behaviour have contrasting associations with markers of low grade inflammation over 4 years of follow-up. These behaviours may be important in influencing the pro-inflammatory state seen with ageing.
Authors: Breno Q Farah; Raphael M Ritti-Dias; Polly S Montgomery; Ana I Casanegra; Federico Silva-Palacios; Andrew W Gardner Journal: J Vasc Surg Date: 2015-10-27 Impact factor: 4.268
Authors: Pascal Izzicupo; Andrea Di Blasio; Andrea Di Credico; Giulia Gaggi; Anastasios Vamvakis; Giorgio Napolitano; Fabrizio Ricci; Sabina Gallina; Barbara Ghinassi; Angela Di Baldassarre Journal: Int J Environ Res Public Health Date: 2020-04-28 Impact factor: 3.390