Literature DB >> 25681573

CXCR3: latest evidence for the involvement of chemokine signaling in bone cancer pain.

Genhua Guo1, Feng Gao2.   

Abstract

Growing evidence indicates that chemokines participate in the generation and maintenance of bone cancer pain (BCP). Recent work in Exp Neurol by Guan et al. (2015) demonstrated the involvement of spinal chemokine receptor CXCR3 and its downstream PI3K/Akt and Raf/MEK/ERK signaling pathways in BCP. This work provides new evidence to support that chemokines participate in central sensitization in BCP condition. Reviewed evidence suggests that few chemokines have been proved to be related to cancer pain. The underlying relationship between CXCR3 signaling and BCP condition requires further study.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Akt; Bone cancer pain; CXCR3; Chemokine; Chronic pain; ERK

Mesh：

Substances：

Year:  2015        PMID： 25681573     DOI： 10.1016/j.expneurol.2015.02.003

Source DB:  PubMed          Journal:  Exp Neurol        ISSN： 0014-4886            Impact factor:   5.330


  10 in total

1.  Involvement of Spinal CCR5/PKCγ Signaling Pathway in the Maintenance of Cancer-Induced Bone Pain.

Authors:  Li-Hua Hang; Shu-Na Li; Xiang Dan; Wei-Wei Shu; Hong Luo; Dong-Hua Shao
Journal:  Neurochem Res       Date:  2016-11-15       Impact factor: 3.996

2.  Minocycline attenuates bone cancer pain in rats by inhibiting NF-κB in spinal astrocytes.

Authors:  Zhen-Peng Song; Bing-Rui Xiong; Xue-Hai Guan; Fei Cao; Anne Manyande; Ya-Qun Zhou; Hua Zheng; Yu-Ke Tian
Journal:  Acta Pharmacol Sin       Date:  2016-05-09       Impact factor: 6.150

3.  CX3CR1-Mediated Akt1 Activation Contributes to the Paclitaxel-Induced Painful Peripheral Neuropathy in Rats.

Authors:  Dai Li; Hui Chen; Xiao-Huan Luo; Yang Sun; Wei Xia; Yuan-Chang Xiong
Journal:  Neurochem Res       Date:  2016-03-09       Impact factor: 3.996

4.  NADPH-Oxidase 2 Promotes Autophagy in Spinal Neurons During the Development of Morphine Tolerance.

Authors:  Xuyang Xiao; Huilian Bu; Zhisong Li; Zheng Li; Qian Bai; Zhitao Wang; Lin Yan; Daiqiang Liu; Xiaoling Peng; Xiaoqian Jia; Feng Gao
Journal:  Neurochem Res       Date:  2021-05-18       Impact factor: 3.996

5.  Oxaliplatin inhibits colorectal cancer progression by inhibiting CXCL11 secreted by cancer-associated fibroblasts and the CXCR3/PI3K/AKT pathway.

Authors:  Caifu Lu; Cong Zhang
Journal:  Clin Transl Oncol       Date:  2022-09-21       Impact factor: 3.340

6.  Upregulation of (C-X-C motif) Ligand 13 (CXCL13) Attenuates Morphine Analgesia in Rats with Cancer-Induced Bone Pain.

Authors:  Shi-Feng Wang; Cheng-Gong Dong; Xue Yang; Jian-Jun Yin
Journal:  Med Sci Monit       Date:  2016-11-28

7.  The circular RNA circSlc7a11 promotes bone cancer pain pathogenesis in rats by modulating LLC-WRC 256 cell proliferation and apoptosis.

Authors:  Han-Wen Chen; Xiao-Xia Zhang; Zhu-Ding Peng; Zu-Min Xing; Yi-Wen Zhang; Ya-Lan Li
Journal:  Mol Cell Biochem       Date:  2021-01-12       Impact factor: 3.396

Review 8.  Treatment of Cancer Pain by Targeting Cytokines.

Authors:  I Vendrell; D Macedo; I Alho; M R Dionísio; L Costa
Journal:  Mediators Inflamm       Date:  2015-10-11       Impact factor: 4.711

9.  Rho/ROCK acts downstream of lysophosphatidic acid receptor 1 in modulating P2X3 receptor-mediated bone cancer pain in rats.

Authors:  Jing-Xiang Wu; Xiao-Min Yuan; Qiong Wang; Wang Wei; Mei-Ying Xu
Journal:  Mol Pain       Date:  2016-04-18       Impact factor: 3.395

10.  Endoplasmic Reticulum Stress in Spinal Cord Contributes to the Development of Morphine Tolerance.

Authors:  Daiqiang Liu; Yaqun Zhou; Yawen Peng; Peng Su; Zheng Li; Qiaoqiao Xu; Ye Tu; Xuebi Tian; Hui Yang; Zhen Wu; Wei Mei; Feng Gao
Journal:  Front Mol Neurosci       Date:  2018-03-06       Impact factor: 5.639
  10 in total

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