BACKGROUND: Chromoblastomycosis (CBM) is a chronic fungal infection caused mainly by the melanized fungi Fonsecaea species. The chronic lesions may be predisposed to develop into cancer, the most serious complication of the disease. METHODS: In this report, 7 cases of squamous cell carcinoma (SCC) resulting from chronic CBM in patients from Maranhão in the Brazilian Amazon are described. RESULTS: The 7 patients presented with SCC that resulted from chronic CBM, caused by Fonsecaea species >10 years' duration. The malignant lesions occurred independent of the antifungal therapy and all patients underwent curative amputation, except for 1 patient who developed metastases in the inguinal and intra-abdominal lymph nodes and thigh muscles. A majority of previous reports have focused on the malignant transformation of CBM described in only 1 patient each. This is a first report describing a group of patients from a single Brazilian state. CONCLUSIONS: Here, we provide new epidemiologic data on malignant CBM lesions, an endemic disease that is seemingly neglected worldwide. We reinforce the idea that typically chronic lesions may be predisposed to turn malignant.
BACKGROUND:Chromoblastomycosis (CBM) is a chronic fungal infection caused mainly by the melanized fungi Fonsecaea species. The chronic lesions may be predisposed to develop into cancer, the most serious complication of the disease. METHODS: In this report, 7 cases of squamous cell carcinoma (SCC) resulting from chronic CBM in patients from Maranhão in the Brazilian Amazon are described. RESULTS: The 7 patients presented with SCC that resulted from chronic CBM, caused by Fonsecaea species >10 years' duration. The malignant lesions occurred independent of the antifungal therapy and all patients underwent curative amputation, except for 1 patient who developed metastases in the inguinal and intra-abdominal lymph nodes and thigh muscles. A majority of previous reports have focused on the malignant transformation of CBM described in only 1 patient each. This is a first report describing a group of patients from a single Brazilian state. CONCLUSIONS: Here, we provide new epidemiologic data on malignant CBM lesions, an endemic disease that is seemingly neglected worldwide. We reinforce the idea that typically chronic lesions may be predisposed to turn malignant.
Authors: Renata R Gomes; Vania A Vicente; Conceição M P S de Azevedo; Claudio G Salgado; Moises B da Silva; Flávio Queiroz-Telles; Sirlei G Marques; Daniel W C L Santos; Tania S de Andrade; Elizabeth H Takagi; Katia S Cruz; Gheniffer Fornari; Rosane C Hahn; Maria L Scroferneker; Rachel B Caligine; Mauricio Ramirez-Castrillon; Daniella P de Araújo; Daiane Heidrich; Arnaldo L Colombo; G S de Hoog Journal: PLoS Negl Trop Dis Date: 2016-11-28
Authors: Sagarika Banerjee; Tian Tian; Zhi Wei; Kristen N Peck; Natalie Shih; Ara A Chalian; Bert W O'Malley; Gregory S Weinstein; Michael D Feldman; James Alwine; Erle S Robertson Journal: Sci Rep Date: 2017-06-22 Impact factor: 4.379
Authors: Vania A Vicente; Vinícius A Weiss; Amanda Bombassaro; Leandro F Moreno; Flávia F Costa; Roberto T Raittz; Aniele C Leão; Renata R Gomes; Anamelia L Bocca; Gheniffer Fornari; Raffael J A de Castro; Jiufeng Sun; Helisson Faoro; Michelle Z Tadra-Sfeir; Valter Baura; Eduardo Balsanelli; Sandro R Almeida; Suelen S Dos Santos; Marcus de Melo Teixeira; Maria S Soares Felipe; Mariana Machado Fidelis do Nascimento; Fabio O Pedrosa; Maria B Steffens; Derlene Attili-Angelis; Mohammad J Najafzadeh; Flávio Queiroz-Telles; Emanuel M Souza; Sybren De Hoog Journal: Front Microbiol Date: 2017-10-09 Impact factor: 5.640
Authors: Aline Grasielli Monçale Campos; Laísa Ezaguy de Hollanda; Louise Makarem Oliveira; Fabio Francesconi do Valle; Valeska Albuquerque Francesconi do Valle Journal: JAAD Case Rep Date: 2018-10-08
Authors: Sagarika Banerjee; Tian Tian; Zhi Wei; Natalie Shih; Michael D Feldman; Kristen N Peck; Angela M DeMichele; James C Alwine; Erle S Robertson Journal: Front Microbiol Date: 2018-05-15 Impact factor: 5.640