Weidong Liu1, Zhichang Liu1, Zhenjiang Yao1, Yanping Fan1, Xiaohua Ye1, Sidong Chen2. 1. Guangdong Key Laboratory of Molecular Epidemiology, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China. 2. Guangdong Key Laboratory of Molecular Epidemiology, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China. Electronic address: chensidong1@126.com.
Abstract
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is becoming a serious epidemic worldwide. Recently, studies have shown that people in contact with livestock may have a greater chance of MRSA carriage. We aimed to establish the prevalence of MRSA among people in contact with livestock and review the factors influencing MRSA carriage. METHODS: We systematically examined published epidemiologic studies on MRSA prevalence in people in contact with livestock using Pubmed, Medline, Embase, Ovid, and the Cochrane Library. Prevalence estimates were pooled using a random-effects model. Study heterogeneity was assessed using Q statistics and quantified with I(2) statistics. RESULTS: Thirty-three eligible studies were included in this systematic review. Prevalence of MRSA ranged from 0.0%-85.8%. The pooled prevalence estimate of MRSA was 14.2% (95% confidence interval, 9.1%-20.1%) for people in contact with livestock. Substantial heterogeneity in eligible studies was noted (χ(2) = 1,025; P < .001; I(2) = 96.9%). Subgroup analysis showed the prevalence of MRSA was high in people from Europe (15.9%), farmers (18.2%), and by longitudinal study design (38.9%). Animal contact and intensity of animal contact were associated with increased risk of MRSA carriage. CONCLUSION: Our findings suggest that there may be transmission of MRSA between animals and humans.
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is becoming a serious epidemic worldwide. Recently, studies have shown that people in contact with livestock may have a greater chance of MRSA carriage. We aimed to establish the prevalence of MRSA among people in contact with livestock and review the factors influencing MRSA carriage. METHODS: We systematically examined published epidemiologic studies on MRSA prevalence in people in contact with livestock using Pubmed, Medline, Embase, Ovid, and the Cochrane Library. Prevalence estimates were pooled using a random-effects model. Study heterogeneity was assessed using Q statistics and quantified with I(2) statistics. RESULTS: Thirty-three eligible studies were included in this systematic review. Prevalence of MRSA ranged from 0.0%-85.8%. The pooled prevalence estimate of MRSA was 14.2% (95% confidence interval, 9.1%-20.1%) for people in contact with livestock. Substantial heterogeneity in eligible studies was noted (χ(2) = 1,025; P < .001; I(2) = 96.9%). Subgroup analysis showed the prevalence of MRSA was high in people from Europe (15.9%), farmers (18.2%), and by longitudinal study design (38.9%). Animal contact and intensity of animal contact were associated with increased risk of MRSA carriage. CONCLUSION: Our findings suggest that there may be transmission of MRSA between animals and humans.
Authors: Valentina Mascaro; Lorena Squillace; Carmelo Ga Nobile; Rosa Papadopoli; Thijs Bosch; Leo M Schouls; Francesco Casalinuovo; Rosanna Musarella; Maria Pavia Journal: Infect Drug Resist Date: 2019-08-20 Impact factor: 4.003