Sarah J Kotecha1, W John Watkins1, A John Henderson2, Sailesh Kotecha3. 1. Department of Child Health, School of Medicine, Cardiff University, Cardiff, United Kingdom. 2. Department of Community-based Medicine, University of Bristol, Bristol, United Kingdom. 3. Department of Child Health, School of Medicine, Cardiff University, Cardiff, United Kingdom. Electronic address: KotechaS@cardiff.ac.uk.
Abstract
OBJECTIVE: To evaluate how birth weight affects lung function measurements in childhood and adolescence in term-born children. STUDY DESIGN: We used data for white, term-born, singletons, from the Avon Longitudinal Study of Parents and Children to determine the association between birth weight and lung function at age 8-9 (n=4086) and 14-17 (n=2582) years. z-scores for lung function measures, adjusted for sex, height, and age, were modeled in terms of birth weight z-score adjusted for sex. In addition, gestation and head circumference then confounders (maternal smoking during pregnancy and social class) were added to the model. RESULTS: At age 8-9 years, birth weight z-scores were significantly associated with lung function z-scores (forced expiratory volume in 1 second, forced vital capacity [FVC], and forced mid-expiratory flow between 25% and 75% of FVC). These relationships essentially were unchanged when birth weight z-scores were further adjusted for gestation, head circumference, and confounders, except for forced mid-expiratory flow between 25% and 75% of FVC, which was no longer significant after we adjusted for head circumference and confounders. At age 14-17 years, the associations between adjusted birth-weight z-scores and spirometry z-scores were in general not significant. Estimated differences for forced expiratory volume in 1 second were 30 mL at ages 8-9 years and 33 mL at 14-17 years for 1 kg change in birth-weight standardized for gestation and sex. CONCLUSIONS: Birth weight is associated with lung function in term-born children at 8-9 years, but less so at 14-17 years, suggesting that birth weight influences lung function in early childhood but has lesser effect later in life.
OBJECTIVE: To evaluate how birth weight affects lung function measurements in childhood and adolescence in term-born children. STUDY DESIGN: We used data for white, term-born, singletons, from the Avon Longitudinal Study of Parents and Children to determine the association between birth weight and lung function at age 8-9 (n=4086) and 14-17 (n=2582) years. z-scores for lung function measures, adjusted for sex, height, and age, were modeled in terms of birth weight z-score adjusted for sex. In addition, gestation and head circumference then confounders (maternal smoking during pregnancy and social class) were added to the model. RESULTS: At age 8-9 years, birth weight z-scores were significantly associated with lung function z-scores (forced expiratory volume in 1 second, forced vital capacity [FVC], and forced mid-expiratory flow between 25% and 75% of FVC). These relationships essentially were unchanged when birth weight z-scores were further adjusted for gestation, head circumference, and confounders, except for forced mid-expiratory flow between 25% and 75% of FVC, which was no longer significant after we adjusted for head circumference and confounders. At age 14-17 years, the associations between adjusted birth-weight z-scores and spirometry z-scores were in general not significant. Estimated differences for forced expiratory volume in 1 second were 30 mL at ages 8-9 years and 33 mL at 14-17 years for 1 kg change in birth-weight standardized for gestation and sex. CONCLUSIONS: Birth weight is associated with lung function in term-born children at 8-9 years, but less so at 14-17 years, suggesting that birth weight influences lung function in early childhood but has lesser effect later in life.
Authors: Agnes Luzak; Elaine Fuertes; Claudia Flexeder; Marie Standl; Andrea von Berg; Dietrich Berdel; Sibylle Koletzko; Joachim Heinrich; Dennis Nowak; Holger Schulz Journal: Respir Res Date: 2017-07-12
Authors: Baoting He; Man Ki Kwok; Shiu Lun Au Yeung; Shi Lin Lin; June Yue Yan Leung; Lai Ling Hui; Albert M Li; Gabriel M Leung; C Mary Schooling Journal: Sci Rep Date: 2020-01-15 Impact factor: 4.379