Hanneke E Hulst1, Menno M Schoonheim2, Quinten Van Geest2, Bernard M J Uitdehaag3, Frederik Barkhof4, Jeroen J G Geurts2. 1. Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, The Netherlands he.hulst@vumc.nl. 2. Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, The Netherlands. 3. Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands. 4. Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
Abstract
BACKGROUND: Memory impairment is frequent in multiple sclerosis (MS), but it is unclear what functional brain changes underlie this cognitive deterioration. OBJECTIVE: To investigate functional hippocampal activation and connectivity, in relation to memory performance in MS. METHODS: Structural and functional magnetic resonance imaging data were acquired for 57 MS patients and 28 healthy controls (HCs), yielding hippocampal measures of volume, lesions, functional activation during a memory task and functional connectivity at rest. Memory function was based on two subtests of a larger neuropsychological test battery and related to hippocampal neuroimaging measures, using linear regression. RESULTS: Hippocampal volume was lower in MS patients, as compared to HCs. In MS, hippocampal activation during the task was increased in cognitively preserved, but decreased in cognitively impaired, patients. Increased hippocampal connectivity was detected in MS patients, as compared to HCs, between the left hippocampus and the right posterior cingulate. Memory impairment in MS was explained (adjusted R(2) = 0.27) by male gender, decreased hippocampal activation and increased hippocampal connectivity (p = 0.001). CONCLUSIONS: Decreased activation of the hippocampus, increased connectivity and male gender were associated with worse memory performance in MS. These results indicate that increased activation and increased connectivity do not always coincide, and relate differently to cognitive dysfunction in MS.
BACKGROUND:Memory impairment is frequent in multiple sclerosis (MS), but it is unclear what functional brain changes underlie this cognitive deterioration. OBJECTIVE: To investigate functional hippocampal activation and connectivity, in relation to memory performance in MS. METHODS: Structural and functional magnetic resonance imaging data were acquired for 57 MS patients and 28 healthy controls (HCs), yielding hippocampal measures of volume, lesions, functional activation during a memory task and functional connectivity at rest. Memory function was based on two subtests of a larger neuropsychological test battery and related to hippocampal neuroimaging measures, using linear regression. RESULTS: Hippocampal volume was lower in MS patients, as compared to HCs. In MS, hippocampal activation during the task was increased in cognitively preserved, but decreased in cognitively impaired, patients. Increased hippocampal connectivity was detected in MS patients, as compared to HCs, between the left hippocampus and the right posterior cingulate. Memory impairment in MS was explained (adjusted R(2) = 0.27) by male gender, decreased hippocampal activation and increased hippocampal connectivity (p = 0.001). CONCLUSIONS: Decreased activation of the hippocampus, increased connectivity and male gender were associated with worse memory performance in MS. These results indicate that increased activation and increased connectivity do not always coincide, and relate differently to cognitive dysfunction in MS.
Authors: Fei Gao; Xuntao Yin; Richard A E Edden; Alan C Evans; Junhai Xu; Guanmei Cao; Honghao Li; Muwei Li; Bin Zhao; Jian Wang; Guangbin Wang Journal: Hippocampus Date: 2018-11 Impact factor: 3.899
Authors: Vincent Planche; Ismail Koubiyr; José E Romero; José V Manjon; Pierrick Coupé; Mathilde Deloire; Vincent Dousset; Bruno Brochet; Aurélie Ruet; Thomas Tourdias Journal: Hum Brain Mapp Date: 2018-01-13 Impact factor: 5.038
Authors: Jolanda Derks; Anne R Dirkson; Philip C de Witt Hamer; Quinten van Geest; Hanneke E Hulst; Frederik Barkhof; Petra J W Pouwels; Jeroen J G Geurts; Jaap C Reijneveld; Linda Douw Journal: Neuroimage Clin Date: 2017-01-16 Impact factor: 4.881
Authors: Björn H Schott; Martin Voss; Benjamin Wagner; Torsten Wüstenberg; Emrah Düzel; Joachim Behr Journal: Front Behav Neurosci Date: 2015-06-01 Impact factor: 3.558
Authors: James F Sumowski; Ralph Benedict; Christian Enzinger; Massimo Filippi; Jeroen J Geurts; Paivi Hamalainen; Hanneke Hulst; Matilde Inglese; Victoria M Leavitt; Maria A Rocca; Eija M Rosti-Otajarvi; Stephen Rao Journal: Neurology Date: 2018-01-17 Impact factor: 9.910