Hsuan Lai1, Caroline V Choong2, Stephanie Fook-Chong3, Yih Yng Ng4, Eric A Finkelstein5, Benjamin Haaland6, E Shaun Goh7, Benjamin Sieu-Hon Leong8, Han Nee Gan9, David Foo10, Lai Peng Tham11, Rabind Charles12, Marcus Eng Hock Ong13. 1. Duke-NUS Graduate School of Medicine, Singapore. 2. Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore. 3. Division of Research, Singapore General Hospital, Singapore. 4. Medical Department, Singapore Civil Defence Force, Singapore. 5. Health Services & Systems Research, Duke-NUS Graduate School of Medicine, Singapore. 6. Centre for Quantitative Medicine, Duke-NUS Graduate School of Medicine, Singapore; Department of Statistics and Applied Probability, National University of Singapore, Singapore. 7. Acute and Emergency Care Centre, Khoo Teck Puat Hospital, Singapore. 8. Emergency Medicine Department, National University Hospital, Singapore. 9. Accident & Emergency, Changi General Hospital, Singapore. 10. Department of Cardiology, Tan Tock Seng Hospital, Singapore. 11. Children's Emergency, KK Women's and Children's Hospital, Singapore. 12. Emergency Medicine Department, Alexandra Hospital, Singapore. 13. Department of Emergency Medicine, Singapore General Hospital, Singapore; Health Services & Systems Research, Duke-NUS Graduate School of Medicine, Singapore. Electronic address: marcus.ong.e.h@sgh.com.sg.
Abstract
AIM: We aim to study if there has been an improvement in survival for Out-of-Hospital Cardiac Arrest (OHCA) in Singapore, the effects of various interventional strategies over the past 10 years, and identify strategies that contributed to improved survival. METHODS: Rates of OHCA survival were compared between 2001-2004 and 2010-2012, using nationwide data for all OHCA presenting to EMS and public hospitals. A multivariate logistic regression model for survival to discharge was constructed to identify strategies with significant impact. RESULTS: A total of 5453 cases were included, 2428 cases from 2001 to 2004 and 3025 cases from 2010 to 2012. There was significant improvement in Utstein (witnessed, shockable) survival to discharge from 2001-2004 (2.5%) to 2010-2012 (11.0%), adjusted odds ratio (OR) 9.6 [95% CI: 2.2-41.9]). Overall survival to discharge increased from 1.6% to 3.2% (adjusted OR 2.2 [1.5-3.3]). Bystander CPR rates increased from 19.7% to 22.4% (p=0.02). The multivariate regression model (adjusted for important non-modifiable risk factors) showed that response time <8min (OR 1.5 [1.0-2.3]), bystander AED (OR 5.8 [2.0-16.2]), and post-resuscitation hypothermia (OR 30.0 [11.5-78.0]) were significantly associated with survival to hospital discharge. Conversely, pre-hospital epinephrine (OR 0.6 [0.4-0.9]) was associated negatively with survival. CONCLUSIONS: OHCA survival has improved in Singapore over the past 10 years. Improvement in response time, public AEDs and post-resuscitation hypothermia appear to have contributed to the increase in survival. Singapore's experience might suggest that developing EMS systems should focus on reducing times to basic life support, including bystander defibrillation and post-resuscitation care.
AIM: We aim to study if there has been an improvement in survival for Out-of-Hospital Cardiac Arrest (OHCA) in Singapore, the effects of various interventional strategies over the past 10 years, and identify strategies that contributed to improved survival. METHODS: Rates of OHCA survival were compared between 2001-2004 and 2010-2012, using nationwide data for all OHCA presenting to EMS and public hospitals. A multivariate logistic regression model for survival to discharge was constructed to identify strategies with significant impact. RESULTS: A total of 5453 cases were included, 2428 cases from 2001 to 2004 and 3025 cases from 2010 to 2012. There was significant improvement in Utstein (witnessed, shockable) survival to discharge from 2001-2004 (2.5%) to 2010-2012 (11.0%), adjusted odds ratio (OR) 9.6 [95% CI: 2.2-41.9]). Overall survival to discharge increased from 1.6% to 3.2% (adjusted OR 2.2 [1.5-3.3]). Bystander CPR rates increased from 19.7% to 22.4% (p=0.02). The multivariate regression model (adjusted for important non-modifiable risk factors) showed that response time <8min (OR 1.5 [1.0-2.3]), bystander AED (OR 5.8 [2.0-16.2]), and post-resuscitation hypothermia (OR 30.0 [11.5-78.0]) were significantly associated with survival to hospital discharge. Conversely, pre-hospital epinephrine (OR 0.6 [0.4-0.9]) was associated negatively with survival. CONCLUSIONS: OHCA survival has improved in Singapore over the past 10 years. Improvement in response time, public AEDs and post-resuscitation hypothermia appear to have contributed to the increase in survival. Singapore's experience might suggest that developing EMS systems should focus on reducing times to basic life support, including bystander defibrillation and post-resuscitation care.
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