Hina Usman1, Rida Rashid1, Fatima Ameer1, Areeb Iqbal1, Muhammad Zaid1, Shahida Hasnain1, Hubert Kalbacher2, Nousheen Zaidi3. 1. Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan. 2. Medical and Natural Sciences Research Centre, University of Tubingen, Germany. 3. Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan. Electronic address: nzzaidi@yahoo.com.
Abstract
BACKGROUND: Previous studies appreciate the leukemia-associated alterations in plasma lipid profiles but fail to provide a consistent pattern of lipid anomalies in leukemia patients. These inconsistencies could be due to overlooking the effects of related confounding risk-factors and comorbidities. METHODS: The plasma lipid profiles of acute-leukemia and control groups were compared. RESULTS: We observed that acute lymphocytic leukemia (ALL) patients display significantly higher triglycerides and very low-density lipoproteins, whereas, acute myeloid leukemia (AML) patients display significantly lower high-density lipoproteins. To assess the confounding effects of related risk factors gender-, age- and BMI-based analyses were performed. We observed that the aforementioned significant differences in the lipid profiles of leukemia patients were restricted to female participants of the respective groups. Moreover, a significant decrease in total cholesterol and low-density lipoprotein levels was observed only in male participants of the AML population. Various age-specific trends in plasma lipid profile of the leukemia patients were also observed. BMI-based analysis did not display many significant differences from the overall analyses. In addition to comparing the absolute values of plasma lipids in leukemia and control groups we also compared and observed significant differences in prevalence of various isolated- and mixed-dyslipidemias in these groups. CONCLUSIONS: These findings may help in outlining the prevalence and types of dyslipidemia in leukemia patients that may emerge as diagnostic/prognostic factors for the management of acute leukemia.
BACKGROUND: Previous studies appreciate the leukemia-associated alterations in plasma lipid profiles but fail to provide a consistent pattern of lipidanomalies in leukemiapatients. These inconsistencies could be due to overlooking the effects of related confounding risk-factors and comorbidities. METHODS: The plasma lipid profiles of acute-leukemia and control groups were compared. RESULTS: We observed that acute lymphocytic leukemia (ALL) patients display significantly higher triglycerides and very low-density lipoproteins, whereas, acute myeloid leukemia (AML) patients display significantly lower high-density lipoproteins. To assess the confounding effects of related risk factors gender-, age- and BMI-based analyses were performed. We observed that the aforementioned significant differences in the lipid profiles of leukemiapatients were restricted to female participants of the respective groups. Moreover, a significant decrease in total cholesterol and low-density lipoprotein levels was observed only in male participants of the AML population. Various age-specific trends in plasma lipid profile of the leukemiapatients were also observed. BMI-based analysis did not display many significant differences from the overall analyses. In addition to comparing the absolute values of plasma lipids in leukemia and control groups we also compared and observed significant differences in prevalence of various isolated- and mixed-dyslipidemias in these groups. CONCLUSIONS: These findings may help in outlining the prevalence and types of dyslipidemia in leukemiapatients that may emerge as diagnostic/prognostic factors for the management of acute leukemia.