Li Li1, Li-Zhu Guo2, Jie Li2, Ying Wang2, Xin Liu2, Ya-Hui Lv2, Chang-Sheng Ma2,3. 1. Cardiovascular Center, Beijing Tong Ren Hospital, Capital University of Medical Sciences, 100730, Beijing, China. ellentmc2010@hotmail.com. 2. Cardiovascular Center, Beijing Tong Ren Hospital, Capital University of Medical Sciences, 100730, Beijing, China. 3. Atrial Fibrillation Center, Cardiology Department, Beijing An Zhen Hospital, Capital University of Medical Sciences, 100029, Beijing, China.
Abstract
PURPOSE: This study aimed to determine blood pressure characteristics and long-term progress in patients with white coat hypertension (WCH) and obstructive sleep apnea (OSA). METHODS: Systolic blood pressure (SBP) and diastolic blood pressure (DBP) and sleep test results over a period of 26 months were analyzed from WCH patients with OSA (n = 28), WCH patients (n = 23), and healthy control subjects (n = 27). RESULTS: At the end of observation, WCH patients with OSA presented significantly increased daytime and nighttime BP and lower diurnal difference of SBP (all Ps < 0.05) and the increased rate of "non-dipper" status (SBP 28.6 %, DBP 32.1 %) was significantly higher when compared with WCH and control groups (all Ps < 0.01). Sustained hypertension was observed in 42.8 % of the WCH patients with OSA, which was significantly higher than that in the WCH and control groups (Ps < 0.01) and was predicted by non-dipper status via 24-h ambulatory SBP/DBP monitoring (Ps < 0.05). CONCLUSION: WCH may represent a prehypertension status, which could develop into sustained hypertension with OSA.
PURPOSE: This study aimed to determine blood pressure characteristics and long-term progress in patients with white coat hypertension (WCH) and obstructive sleep apnea (OSA). METHODS: Systolic blood pressure (SBP) and diastolic blood pressure (DBP) and sleep test results over a period of 26 months were analyzed from WCH patients with OSA (n = 28), WCH patients (n = 23), and healthy control subjects (n = 27). RESULTS: At the end of observation, WCH patients with OSA presented significantly increased daytime and nighttime BP and lower diurnal difference of SBP (all Ps < 0.05) and the increased rate of "non-dipper" status (SBP 28.6 %, DBP 32.1 %) was significantly higher when compared with WCH and control groups (all Ps < 0.01). Sustained hypertension was observed in 42.8 % of the WCH patients with OSA, which was significantly higher than that in the WCH and control groups (Ps < 0.01) and was predicted by non-dipper status via 24-h ambulatory SBP/DBP monitoring (Ps < 0.05). CONCLUSION: WCH may represent a prehypertension status, which could develop into sustained hypertension with OSA.
Entities:
Keywords:
Blood pressure; Non-dipper; Obstructive sleep apnea; White coat hypertension
Authors: T Hori; Y Sugita; E Koga; S Shirakawa; K Inoue; S Uchida; H Kuwahara; M Kousaka; T Kobayashi; Y Tsuji; M Terashima; K Fukuda; N Fukuda Journal: Psychiatry Clin Neurosci Date: 2001-06 Impact factor: 5.188