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Literature DB >> 25680409

Hedgehog pathway aberrations and gastric cancer; evaluation of prognostic impact and exploration of therapeutic potentials.

Abstract

Gastric cancer is an important cause for mortality and morbidity worldwide; it lies in the fourt rank as a cause of cancer-related death in males and in the fifth rank of cancer-related death in women. The prognosis of advanced/metastatic gastric cancer cases looks poor with the majority of available therapeutics. Thus, novel therapeutic strategies in this setting have been considered a priority for leading cooperative oncology groups. Hedgehog(Hh) pathway aberrations have sparked particular interest as prognostic markers with data from multiple studies showing consistent evidence of a poor prognostic value of Gli over expression in gastric cancer while on the other hand the prognostic significance of Hh protein over expression (particularly SHH) was not consistent among different studies. This review article revises the prognostic and potential therapeutic opportunities in the targeting of hedgehog pathway in gastric cancer.

Entities: Disease Gene Species

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Year: 2015 PMID： 25680409 DOI： 10.1007/s13277-015-3216-6

Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283

33 in total

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Journal: Mol Med Rep Date: 2013-02-21 Impact factor: 2.952

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14 in total

1. The relationship between five non-synonymous polymorphisms within three XRCC genes and gastric cancer risk in a Han Chinese population.

Authors: Huansong Gong; He Li; Jing Zou; Jia Mi; Fang Liu; Dan Wang; Dong Yan; Bin Wang; Shuping Zhang; Geng Tian
Journal: Tumour Biol Date: 2015-11-21

2. Protein arginine methyltransferase 1 promoted the growth and migration of cancer cells in esophageal squamous cell carcinoma.

Authors: Weizheng Zhou; Hui Yue; Chunguang Li; Hezhong Chen; Yang Yuan
Journal: Tumour Biol Date: 2015-09-22

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Authors: Gianluca Tomasello; Michele Ghidini; Wanda Liguigli; Margherita Ratti; Laura Toppo; Rodolfo Passalacqua
Journal: Invest New Drugs Date: 2016-02-12 Impact factor: 3.850

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Authors: Zi-Ning Lei; Qiu-Xu Teng; Qin Tian; Wei Chen; Yuhao Xie; Kaiming Wu; Qianlin Zeng; Leli Zeng; Yihang Pan; Zhe-Sheng Chen; Yulong He
Journal: Signal Transduct Target Ther Date: 2022-10-08

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Authors: Jianbing Wu; Xi Wang; Wei Lu
Journal: Oncol Lett Date: 2018-06-11 Impact factor: 2.967

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Authors: Shiwei Liu; Xuening Duan; Ling Xu; Jingming Ye; Yuanjia Cheng; Qian Liu; Hong Zhang; Shuang Zhang; Sainan Zhu; Ting Li; Yinhua Liu
Journal: Tumour Biol Date: 2015-11-02