Literature DB >> 25680303

Progress and challenges in generating functional hematopoietic stem/progenitor cells from human pluripotent stem cells.

Senquan Liu1, Yulin Xu2, Zijing Zhou3, Bo Feng4, He Huang5.   

Abstract

The generation of hematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) in vitro holds great potential for providing alternative sources of donor cells for clinical HSC transplantation. However, the low efficiency of current protocols for generating blood lineages and the dysfunction identified in hPSC-derived hematopoietic cells limit their use for full hematopoietic reconstitution in clinics. This review outlines the current understanding of in vitro hematopoietic differentiation from hPSCs, emphasizes the intrinsic and extrinsic molecular mechanisms that are attributed to the aberrant phenotype and function in hPSC-derived hematopoietic cells, pinpoints the current challenges to develop the truly functional HSCs from hPSCs for clinical applications and explores their potential solutions.
Copyright © 2015 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  hematopoietic differentiation; hematopoietic reconstitution; hematopoietic stem cells; human embryonic stem cells; induced pluripotent stem cells

Mesh：

Year:  2015        PMID： 25680303     DOI： 10.1016/j.jcyt.2015.01.003

Source DB:  PubMed          Journal:  Cytotherapy        ISSN： 1465-3249            Impact factor:   5.414


  4 in total

1.  Generation and Analysis of GATA2w/eGFP Human ESCs Reveal ITGB3/CD61 as a Reliable Marker for Defining Hemogenic Endothelial Cells during Hematopoiesis.

Authors:  Ke Huang; Jiao Gao; Juan Du; Ning Ma; Yanling Zhu; Pengfei Wu; Tian Zhang; Wenqian Wang; Yuhang Li; Qianyu Chen; Andrew Paul Hutchins; Zhongzhou Yang; Yi Zheng; Jian Zhang; Yongli Shan; Xuejia Li; Baojian Liao; Jiajun Liu; Jinyong Wang; Bing Liu; Guangjin Pan
Journal:  Stem Cell Reports       Date:  2016-10-13       Impact factor: 7.765

2.  R-spondin2 promotes hematopoietic differentiation of human pluripotent stem cells by activating TGF beta signaling.

Authors:  Yv Wang; Jie Gao; Hongtao Wang; Mengge Wang; Yuqi Wen; Jiaojiao Guo; Pei Su; Lihong Shi; Wen Zhou; Jiaxi Zhou
Journal:  Stem Cell Res Ther       Date:  2019-05-20       Impact factor: 6.832

3.  Enhanced HSC-like cell generation from mouse pluripotent stem cells in a 3D induction system cocultured with stromal cells.

Authors:  Wei Shan; Qin Yu; Yan Long; Qian Luo; Honghu Li; Yingli Han; Yulin Xu; Shan Fu; Xiangjun Zeng; Cong Wei; Yang Gao; Xiaoqing Li; Xia Li; Lifei Zhang; Lizhen Liu; Ming Chen; Pengxu Qian; He Huang
Journal:  Stem Cell Res Ther       Date:  2021-06-19       Impact factor: 6.832

4.  Generation of hematopoietic stem/progenitor cells with sickle cell mutation from induced pluripotent stem cell in serum-free system.

Authors:  Bárbara C M F Paes; Luiza C J R Stabeli; Péricles N M Costa; Maristela Delgado Orellana; Simone Kashima; Dimas Tadeu Covas; Virgínia Picanço-Castro
Journal:  Hematol Transfus Cell Ther       Date:  2020-03-06
  4 in total

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