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Literature DB >> 2567992

Studies on the DNA elongation inhibitor and its proliferating cell nuclear antigen-dependent control in simian virus 40 DNA replication in vitro.

S H Lee¹, A D Kwong, Y Ishimi, J Hurwitz.

Abstract

A 120-kDa protein that blocks DNA termini has been purified from extracts of HeLa cells. This protein inhibits the action of a number of enzymes that catalyze reactions involving the 5' and 3' ends of DNA (DNA ligase, 3' and 5' exonucleases, and DNA polymerase alpha). The 120-kDa protein blocks the synthesis of long DNA chains that are normally formed during simian virus 40 DNA replication, causing the accumulation of small DNA fragments. The effects of this protein can be reversed by the addition of proliferating cell nuclear antigen and other protein fractions (activators).

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Year: 1989 PMID： 2567992 PMCID： PMC297518 DOI： 10.1073/pnas.86.13.4877

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

19 in total

1. Replication and supercoiling of simian virus 40 DNA in cell extracts from human cells.

Authors: B W Stillman; Y Gluzman
Journal: Mol Cell Biol Date: 1985-08 Impact factor: 4.272

2. Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases.

Authors: L M Siegel; K J Monty
Journal: Biochim Biophys Acta Date: 1966-02-07

3. The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro.

Authors: G Prelich; M Kostura; D R Marshak; M B Mathews; B Stillman
Journal: Nature Date: 1987 Apr 2-8 Impact factor: 49.962

4. Replication of simian virus 40 origin-containing DNA in vitro with purified proteins.

Authors: C R Wobbe; L Weissbach; J A Borowiec; F B Dean; Y Murakami; P Bullock; J Hurwitz
Journal: Proc Natl Acad Sci U S A Date: 1987-04 Impact factor: 11.205

5. Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro.

Authors: L Yang; M S Wold; J J Li; T J Kelly; L F Liu
Journal: Proc Natl Acad Sci U S A Date: 1987-02 Impact factor: 11.205

6. Role of DNA polymerase alpha and DNA primase in simian virus 40 DNA replication in vitro.

Authors: Y Murakami; C R Wobbe; L Weissbach; F B Dean; J Hurwitz
Journal: Proc Natl Acad Sci U S A Date: 1986-05 Impact factor: 11.205

7. Purification of a cellular replication factor, RF-C, that is required for coordinated synthesis of leading and lagging strands during simian virus 40 DNA replication in vitro.

Authors: T Tsurimoto; B Stillman
Journal: Mol Cell Biol Date: 1989-02 Impact factor: 4.272

8. Mechanism of DNA elongation catalyzed by Escherichia coli DNA polymerase III, dnaZ protein, and DNA elongation factors I and III.

Authors: S Wickner
Journal: Proc Natl Acad Sci U S A Date: 1976-10 Impact factor: 11.205

9. Simian virus 40 DNA replication in vitro.

Authors: J J Li; T J Kelly
Journal: Proc Natl Acad Sci U S A Date: 1984-11 Impact factor: 11.205

10. In vitro replication of duplex circular DNA containing the simian virus 40 DNA origin site.

Authors: C R Wobbe; F Dean; L Weissbach; J Hurwitz
Journal: Proc Natl Acad Sci U S A Date: 1985-09 Impact factor: 11.205

17 in total

1. Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells.

Authors: M Chen; Z Q Pan; J Hurwitz
Journal: Proc Natl Acad Sci U S A Date: 1992-04-01 Impact factor: 11.205

2. Identification of a specific inhibitor for DNA ligase I in human cells.

Authors: S W Yang; F F Becker; J Y Chan
Journal: Proc Natl Acad Sci U S A Date: 1992-03-15 Impact factor: 11.205

3. DNA polymerase delta isolated from Schizosaccharomyces pombe contains five subunits.

Authors: S Zuo; E Gibbs; Z Kelman; T S Wang; M O'Donnell; S A MacNeill; J Hurwitz
Journal: Proc Natl Acad Sci U S A Date: 1997-10-14 Impact factor: 11.205

4. RFC3 regulates cell proliferation and pathogen resistance in Arabidopsis.

Authors: Shitou Xia; Langtao Xiao; Patrick Gannon; Xin Li
Journal: Plant Signal Behav Date: 2010-02-05

5. Synthesis of DNA containing the simian virus 40 origin of replication by the combined action of DNA polymerases alpha and delta.

Authors: S H Lee; T Eki; J Hurwitz
Journal: Proc Natl Acad Sci U S A Date: 1989-10 Impact factor: 11.205

6. trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon.

Authors: J H Küpper; M Müller; M K Jacobson; J Tatsumi-Miyajima; D L Coyle; E L Jacobson; A Bürkle
Journal: Mol Cell Biol Date: 1995-06 Impact factor: 4.272

7. Multiple functions of human single-stranded-DNA binding protein in simian virus 40 DNA replication: single-strand stabilization and stimulation of DNA polymerases alpha and delta.

Authors: M K Kenny; S H Lee; J Hurwitz
Journal: Proc Natl Acad Sci U S A Date: 1989-12 Impact factor: 11.205