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Literature DB >> 25679030

Hippo signalling directs intestinal fate.

Abstract

Hippo signalling has been associated with many important tissue functions including the regulation of organ size. In the intestinal epithelium differing functions have been proposed for the effectors of Hippo signalling, YAP and TAZ1. These are now shown to have a dual role in the intestinal epithelium, regulating both stem cell proliferation and differentiation along a specific secretory lineage.

Entities: Gene

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Year: 2015 PMID： 25679030 DOI： 10.1038/ncb3086

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

14 in total

1. Dual role of YAP and TAZ in renewal of the intestinal epithelium.

Authors: Masamichi Imajo; Miki Ebisuya; Eisuke Nishida
Journal: Nat Cell Biol Date: 2014-12-22 Impact factor: 28.824

2. YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response.

Authors: Luca Azzolin; Tito Panciera; Sandra Soligo; Elena Enzo; Silvio Bicciato; Sirio Dupont; Silvia Bresolin; Chiara Frasson; Giuseppe Basso; Vincenza Guzzardo; Ambrogio Fassina; Michelangelo Cordenonsi; Stefano Piccolo
Journal: Cell Date: 2014-06-26 Impact factor: 41.582

Review 3. RNAi screening comes of age: improved techniques and complementary approaches.

Authors: Stephanie E Mohr; Jennifer A Smith; Caroline E Shamu; Ralph A Neumüller; Norbert Perrimon
Journal: Nat Rev Mol Cell Biol Date: 2014-09 Impact factor: 94.444

4. Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance.

Authors: Dawang Zhou; Yongyou Zhang; Hongtan Wu; Evan Barry; Yi Yin; Earl Lawrence; Dawn Dawson; Joseph E Willis; Sanford D Markowitz; Fernando D Camargo; Joseph Avruch
Journal: Proc Natl Acad Sci U S A Date: 2011-10-31 Impact factor: 11.205

Hippo signalling directs intestinal fate.

1. Dual role of YAP and TAZ in renewal of the intestinal epithelium.

2. YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response.

Review 3. RNAi screening comes of age: improved techniques and complementary approaches.

4. Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance.

5. Hemagglutinating virus of Japan (HVJ) envelope vector as a versatile gene delivery system.

6. YAP1 increases organ size and expands undifferentiated progenitor cells.

7. Adenovirus-mediated transduction of intestinal cells in vivo.

Review 8. The hippo signaling pathway in development and cancer.

9. The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.

10. RNAi screens in mice identify physiological regulators of oncogenic growth.

1. Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses.

Review 2. Dual roles of yes-associated protein (YAP) in colorectal cancer.

Review 3. The role of the Hippo pathway in the pathogenesis of inflammatory bowel disease.

Review 4. YAP and TAZ Mediators at the Crossroad between Metabolic and Cellular Reprogramming.