Literature DB >> 2567894

Inositol 1,4,5-trisphosphate phosphatase deficiency and malignant hyperpyrexia in swine.

P S Foster1, E Gesini, C Claudianos, K C Hopkinson, M A Denborough.   

Abstract

The sarcoplasmic reticulum from muscle of swine which are susceptible to malignant hyperpyrexia is deficient in inositol 1,4,5-trisphosphate phosphatase (InsP35-ase) activity, which leads to high intracellular concentrations of inositol 1,4,5-trisphosphate (InsP3) and of calcium ions. Halothane inhibits InsP35-ase and further increases myoplasmic InsP3 and calcium ion concentrations, and produces the clinical features of malignant hyperpyrexia.

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Year:  1989        PMID： 2567894     DOI： 10.1016/s0140-6736(89)90182-7

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  7 in total

1.  Effects of the 5-HT2 receptor antagonist ritanserin on halothane-induced increase of inositol phosphates in porcine malignant hyperthermia.

Authors:  A Richter; J Scholz; W Löscher; P H Tonner; F Wappler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-11       Impact factor: 3.000

2.  Mechanical stimulation and intercellular communication increases intracellular Ca2+ in epithelial cells.

Authors:  M J Sanderson; A C Charles; E R Dirksen
Journal:  Cell Regul       Date:  1990-07

3.  Chemical transmission at the triad: InsP3?

Authors:  E Jaimovich
Journal:  J Muscle Res Cell Motil       Date:  1991-08       Impact factor: 2.698

4.  Inositol 1,4,5-trisphosphate-induced Ca2+ release is regulated by cytosolic Ca2+ in intact skeletal muscle.

Authors:  J R López; A Terzic
Journal:  Pflugers Arch       Date:  1996-09       Impact factor: 3.657

5.  Hypersensitive response of malignant hyperthermia-susceptible skeletal muscle to inositol 1,4,5-triphosphate induced release of calcium.

Authors:  J R López; C Pérez; N Linares; P Allen; A Terzic
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-10       Impact factor: 3.000

Review 6.  The genetics of malignant hyperthermia.

Authors:  S P Ball; K J Johnson
Journal:  J Med Genet       Date:  1993-02       Impact factor: 6.318

7.  Alteration of intracellular Ca2+ transients in COS-7 cells transfected with the cDNA encoding skeletal-muscle ryanodine receptor carrying a mutation associated with malignant hyperthermia.

Authors:  S Treves; F Larini; P Menegazzi; T H Steinberg; M Koval; B Vilsen; J P Andersen; F Zorzato
Journal:  Biochem J       Date:  1994-08-01       Impact factor: 3.857
  7 in total

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