| Literature DB >> 25676377 |
Elisa Piva1, Carlo Brugnara2, Federica Spolaore3, Mario Plebani3.
Abstract
The reticulocyte count reflects the erythropoietic activity of bone marrow and is thus useful in both diagnosing anemias and monitoring bone marrow response to therapy. Automated flow-cytometric analysis has led to a significant advance in reticulocyte counting, by simultaneously providing additional parameters and indices such as the reticulocyte immature reticulocyte fraction (IRF), the reticulocyte volume, and the hemoglobin content and concentration. IRF has been proposed as an early marker of engraftment. Reticulocyte hemoglobin content is useful in assessing the functional iron available for erythropoiesis, and reticulocyte volume is a useful indicator when monitoring the therapeutic response of anemias.Entities:
Keywords: Immature reticulocyte fraction; Reticulocyte; Reticulocyte hemoglobin concentration; Reticulocyte hemoglobin content; Reticulocyte maturation; Reticulocyte volume
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Year: 2014 PMID: 25676377 DOI: 10.1016/j.cll.2014.10.004
Source DB: PubMed Journal: Clin Lab Med ISSN: 0272-2712 Impact factor: 1.935