Emiko Nishioka1, Satoshi Hirayama2, Tsuyoshi Ueno3, Takehisa Matsukawa4, Mohsen Vigeh5, Kazuhito Yokoyama4, Shintaro Makino6, Satoru Takeda6, Takashi Miida3. 1. Department of Epidemiology and Environmental Health, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Department of Midwifery and Women's Health, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Kobe, Hyogo 654-0142, Japan. 2. Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. Electronic address: sthiraya@juntendo.ac.jp. 3. Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. 4. Department of Epidemiology and Environmental Health, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. 5. Department of Epidemiology and Environmental Health, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; National Institute of Occupational Safety and Health, Nagao 6-21-1 Tama-ku, Kawasaki-city, Kanagawa, 204-0024, Japan. 6. Department of Obstetrics and Gynecology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Abstract
OBJECTIVE: Thyroid hormones cross the placenta and promote fetal development and growth. The present study investigated whether an increase in maternal thyroid-stimulating hormone (TSH) concentration between the first and third trimesters is a determinant of birth weight during normal pregnancy. METHODS: Maternal thyroid hormones and TSH were longitudinally measured at 12, 25, and 36weeks of pregnancy in 163 healthy pregnant women. Low birth weight (LBW) was defined as less than 2500g. ∆TSH12-36W was calculated as the difference in TSH concentrations between 12 and 36weeks of pregnancy. RESULTS: Of the 163 neonates, 10 (6.1%) were LBW neonates. Free triiodothyronine and free thyroxine levels were similar at all gestational ages in the normal birth weight (Normal) and LBW groups. However, the median ∆TSH12-36W value was higher in the LBW than the Normal group (1.67 vs. 0.54mIU/L, P=0.008). Multivariate linear regression analysis showed that ∆TSH12-36 was inversely correlated with birth weight (β=-0.179, P=0.008). CONCLUSION: An increase in maternal TSH concentration between the first and third trimesters is an independent determinant of birth weight in normal pregnancy.
OBJECTIVE: Thyroid hormones cross the placenta and promote fetal development and growth. The present study investigated whether an increase in maternal thyroid-stimulating hormone (TSH) concentration between the first and third trimesters is a determinant of birth weight during normal pregnancy. METHODS: Maternal thyroid hormones and TSH were longitudinally measured at 12, 25, and 36weeks of pregnancy in 163 healthy pregnant women. Low birth weight (LBW) was defined as less than 2500g. ∆TSH12-36W was calculated as the difference in TSH concentrations between 12 and 36weeks of pregnancy. RESULTS: Of the 163 neonates, 10 (6.1%) were LBW neonates. Free triiodothyronine and free thyroxine levels were similar at all gestational ages in the normal birth weight (Normal) and LBW groups. However, the median ∆TSH12-36W value was higher in the LBW than the Normal group (1.67 vs. 0.54mIU/L, P=0.008). Multivariate linear regression analysis showed that ∆TSH12-36 was inversely correlated with birth weight (β=-0.179, P=0.008). CONCLUSION: An increase in maternal TSH concentration between the first and third trimesters is an independent determinant of birth weight in normal pregnancy.
Authors: Lauren E Johns; Kelly K Ferguson; David E Cantonwine; Bhramar Mukherjee; John D Meeker; Thomas F McElrath Journal: J Clin Endocrinol Metab Date: 2018-04-01 Impact factor: 5.958
Authors: Shatha A Al Shanqeeti; Yasser N Alkhudairy; Alwaleed A Alabdulwahed; Anwar E Ahmed; Maysoon S Al-Adham; Naveed M Mahmood Journal: Saudi Med J Date: 2018-03 Impact factor: 1.484