| Literature DB >> 2567610 |
B Kirkpatrick1, R W Buchanan, K Maeda, W T Carpenter, D Jauch, C A Tamminga.
Abstract
Stable schizophrenic and schizoaffective outpatients underwent abrupt withdrawal from a fixed dose of neuroleptic. Prolactin concentrations were determined preceding and following drug withdrawal. Basal prolactin concentrations were significantly lower 3, 4, or 5 days following drug withdrawal than on subsequent days. This rebound effect may be related to dopaminergic receptor changes in the tuberoinfundibular system that are induced by chronic neuroleptic administration.Entities:
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Year: 1989 PMID： 2567610 DOI： 10.1016/0006-3223(89)90016-4
Source DB: PubMed Journal: Biol Psychiatry ISSN： 0006-3223 Impact factor: 13.382