Literature DB >> 2567515

A region in the coding sequence is required for high-level expression of murine histone H3 gene.

M M Hurt1, N B Pandey, W F Marzluff.   

Abstract

Replication-dependent histone genes are expressed at high rates in S phase to provide the histone proteins required for chromosomal replication. Two genes, an H2a and H3 gene, located on chromosome 3 in the mouse and cloned together in a single 3-kilobase (plasmid MM614) restriction fragment are highly expressed. By transfecting mouse histone gene constructs into Chinese hamster ovary cells, we have identified a 110-nucleotide region within the coding sequence of the H3.2-614 gene that is required for high-level expression. Deletion of this region reduces expression of the gene by 20-fold. Additionally, the histone-coding region activates the human alpha-globin promoter, which is normally not expressed well in Chinese hamster ovary cells. Similar results with deletion constructions involving the H2a-614 gene suggest that an intragenic region plays an important role in transcription of these genes.

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Year:  1989        PMID： 2567515      PMCID： PMC287287          DOI： 10.1073/pnas.86.12.4450

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

1.  Multiple sequence elements are required for maximal in vitro transcription of a human histone H2B gene.

Authors:  H L Sive; N Heintz; R G Roeder
Journal:  Mol Cell Biol       Date:  1986-10       Impact factor: 4.272

2.  Sequences of four mouse histone H3 genes: implications for evolution of mouse histone genes.

Authors:  J D Taylor; S E Wellman; W F Marzluff
Journal:  J Mol Evol       Date:  1986       Impact factor: 2.395

3.  Translation is required for regulation of histone mRNA degradation.

Authors:  R A Graves; N B Pandey; N Chodchoy; W F Marzluff
Journal:  Cell       Date:  1987-02-27       Impact factor: 41.582

4.  Distinct transcription factors bind specifically to two regions of the human histone H4 promoter.

Authors:  L Dailey; S M Hanly; R G Roeder; N Heintz
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

5.  Factors involved in specific transcription in mammalian RNA polymerase II. Functional analysis of initiation factors IIA and IID and identification of a new factor operating at sequences downstream of the initiation site.

Authors:  D Reinberg; M Horikoshi; R G Roeder
Journal:  J Biol Chem       Date:  1987-03-05       Impact factor: 5.157

6.  Compilation analysis of histones and histone genes.

Authors:  D E Wells
Journal:  Nucleic Acids Res       Date:  1986       Impact factor: 16.971

7.  Identification of promoter elements necessary for transcriptional regulation of a human histone H4 gene in vitro.

Authors:  S M Hanly; G C Bleecker; N Heintz
Journal:  Mol Cell Biol       Date:  1985-02       Impact factor: 4.272

8.  Stimulation of sea urchin H2B histone gene transcription by a chromatin-associated protein fraction depends on gene sequences downstream of the transcription start site.

Authors:  J Mous; H Stunnenberg; O Georgiev; M L Birnstiel
Journal:  Mol Cell Biol       Date:  1985-10       Impact factor: 4.272

9.  Differential expression of two clusters of mouse histone genes.

Authors:  R A Graves; S E Wellman; I M Chiu; W F Marzluff
Journal:  J Mol Biol       Date:  1985-05-25       Impact factor: 5.469

10.  High-frequency transfection of CHO cells using polybrene.

Authors:  W G Chaney; D R Howard; J W Pollard; S Sallustio; P Stanley
Journal:  Somat Cell Mol Genet       Date:  1986-05
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  9 in total

1.  Positive and negative transcriptional regulatory elements in the early H4 histone gene of the sea urchin, Strongylocentrotus purpuratus.

Authors:  L Tung; I J Lee; H L Rice; E S Weinberg
Journal:  Nucleic Acids Res       Date:  1990-12-25       Impact factor: 16.971

2.  A common transcriptional activator is located in the coding region of two replication-dependent mouse histone genes.

Authors:  M M Hurt; T L Bowman; W F Marzluff
Journal:  Mol Cell Biol       Date:  1991-06       Impact factor: 4.272

3.  Cell cycle-regulated binding of nuclear proteins to elements within a mouse H3.2 histone gene.

Authors:  N K Kaludov; T L Bowman; E M Sikorski; M M Hurt
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-30       Impact factor: 11.205

4.  The mouse histone H2a gene contains a small element that facilitates cytoplasmic accumulation of intronless gene transcripts and of unspliced HIV-1-related mRNAs.

Authors:  Y Huang; G G Carmichael
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-16       Impact factor: 11.205

5.  Identification of a second conserved element within the coding sequence of a mouse H3 histone gene that interacts with nuclear factors and is necessary for normal expression.

Authors:  N K Kaludov; L Pabón-Peña; M M Hurt
Journal:  Nucleic Acids Res       Date:  1996-02-01       Impact factor: 16.971

6.  A composite intragenic silencer domain exhibits negative and positive transcriptional control of the bone-specific osteocalcin gene: promoter and cell type requirements.

Authors:  B Frenkel; M Montecino; J L Stein; J B Lian; G S Stein
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-08       Impact factor: 11.205

Review 7.  Utilization of transgenic mice in the study of matrix degrading proteinases and their inhibitors.

Authors:  R Khokha; D C Martin; J E Fata
Journal:  Cancer Metastasis Rev       Date:  1995-06       Impact factor: 9.264

8.  The coding sequences of mouse H2A and H3 histone genes contains a conserved seven nucleotide element that interacts with nuclear factors and is necessary for normal expression.

Authors:  T L Bowman; M M Hurt
Journal:  Nucleic Acids Res       Date:  1995-08-25       Impact factor: 16.971

9.  Role for a YY1-binding element in replication-dependent mouse histone gene expression.

Authors:  K A Eliassen; A Baldwin; E M Sikorski; M M Hurt
Journal:  Mol Cell Biol       Date:  1998-12       Impact factor: 4.272
  9 in total

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