Literature DB >> 25674977

Double trouble: HIV latency and CTL escape.

Matthew D Marsden1, Jerome A Zack2.   

Abstract

HIV can enter a state of latency that allows it to persist for decades in antiretroviral drug-treated patients. In a recent Nature paper, Deng et al. (2015) show that this latent reservoir also contains a large number of cytotoxic T lymphocyte escape mutants, presenting another challenge to HIV cure efforts.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 25674977      PMCID： PMC4375954          DOI： 10.1016/j.chom.2015.01.008

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   21.023


  10 in total

1.  Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy.

Authors:  D Finzi; J Blankson; J D Siliciano; J B Margolick; K Chadwick; T Pierson; K Smith; J Lisziewicz; F Lori; C Flexner; T C Quinn; R E Chaisson; E Rosenberg; B Walker; S Gange; J Gallant; R F Siliciano
Journal:  Nat Med       Date:  1999-05       Impact factor: 53.440

2.  Molecular characterization, reactivation, and depletion of latent HIV.

Authors:  David G Brooks; Dean H Hamer; Philip A Arlen; Lianying Gao; Greg Bristol; Christina M R Kitchen; Edward A Berger; Jerome A Zack
Journal:  Immunity       Date:  2003-09       Impact factor: 31.745

Review 3.  HIV/AIDS eradication.

Authors:  Matthew D Marsden; Jerome A Zack
Journal:  Bioorg Med Chem Lett       Date:  2013-05-18       Impact factor: 2.823

4.  Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus.

Authors:  P Borrow; H Lewicki; X Wei; M S Horwitz; N Peffer; H Meyers; J A Nelson; J E Gairin; B H Hahn; M B Oldstone; G M Shaw
Journal:  Nat Med       Date:  1997-02       Impact factor: 53.440

5.  Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy.

Authors:  T W Chun; L Stuyver; S B Mizell; L A Ehler; J A Mican; M Baseler; A L Lloyd; M A Nowak; A S Fauci
Journal:  Proc Natl Acad Sci U S A       Date:  1997-11-25       Impact factor: 11.205

6.  Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation.

Authors:  Liang Shan; Kai Deng; Neeta S Shroff; Christine M Durand; S Alireza Rabi; Hung-Chih Yang; Hao Zhang; Joseph B Margolick; Joel N Blankson; Robert F Siliciano
Journal:  Immunity       Date:  2012-03-08       Impact factor: 31.745

7.  Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice.

Authors:  Ariel Halper-Stromberg; Ching-Lan Lu; Florian Klein; Joshua A Horwitz; Stylianos Bournazos; Lilian Nogueira; Thomas R Eisenreich; Cassie Liu; Anna Gazumyan; Uwe Schaefer; Rebecca C Furze; Michael S Seaman; Rab Prinjha; Alexander Tarakhovsky; Jeffrey V Ravetch; Michel C Nussenzweig
Journal:  Cell       Date:  2014-08-14       Impact factor: 41.582

8.  Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection.

Authors:  Jintanat Ananworanich; Alexandra Schuetz; Claire Vandergeeten; Irini Sereti; Mark de Souza; Rungsun Rerknimitr; Robin Dewar; Mary Marovich; Frits van Griensven; Rafick Sekaly; Suteeraporn Pinyakorn; Nittaya Phanuphak; Rapee Trichavaroj; Wiriya Rutvisuttinunt; Nitiya Chomchey; Robert Paris; Sheila Peel; Victor Valcour; Frank Maldarelli; Nicolas Chomont; Nelson Michael; Praphan Phanuphak; Jerome H Kim
Journal:  PLoS One       Date:  2012-03-30       Impact factor: 3.240

9.  Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations.

Authors:  Kai Deng; Mihaela Pertea; Anthony Rongvaux; Leyao Wang; Christine M Durand; Gabriel Ghiaur; Jun Lai; Holly L McHugh; Haiping Hao; Hao Zhang; Joseph B Margolick; Cagan Gurer; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Steven G Deeks; Till Strowig; Priti Kumar; Janet D Siliciano; Steven L Salzberg; Richard A Flavell; Liang Shan; Robert F Siliciano
Journal:  Nature       Date:  2015-01-07       Impact factor: 49.962

10.  Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.

Authors:  Ya-Chi Ho; Liang Shan; Nina N Hosmane; Jeffrey Wang; Sarah B Laskey; Daniel I S Rosenbloom; Jun Lai; Joel N Blankson; Janet D Siliciano; Robert F Siliciano
Journal:  Cell       Date:  2013-10-24       Impact factor: 41.582
  10 in total
  9 in total

1.  Experimental Approaches for Eliminating Latent HIV.

Authors:  Matthew D Marsden; Jerome A Zack
Journal:  For Immunopathol Dis Therap       Date:  2015

2.  Accumulation of follicular CD8+ T cells in pathogenic SIV infection.

Authors:  Sara Ferrando-Martinez; Eirini Moysi; Amarendra Pegu; Sarah Andrews; Krystelle Nganou Makamdop; David Ambrozak; Adrian B McDermott; David Palesch; Mirko Paiardini; George N Pavlakis; Jason M Brenchley; Daniel Douek; John R Mascola; Constantinos Petrovas; Richard A Koup
Journal:  J Clin Invest       Date:  2018-04-16       Impact factor: 14.808

3.  Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication.

Authors:  Hayato Murakoshi; Nozomi Kuse; Tomohiro Akahoshi; Yu Zhang; Takayuki Chikata; Mohamed Ali Borghan; Hiroyuki Gatanaga; Shinichi Oka; Keiko Sakai; Masafumi Takiguchi
Journal:  J Virol       Date:  2018-12-10       Impact factor: 5.103

Review 4.  Challenges and Opportunities for T-Cell-Mediated Strategies to Eliminate HIV Reservoirs.

Authors:  Mark A Brockman; R Brad Jones; Zabrina L Brumme
Journal:  Front Immunol       Date:  2015-10-02       Impact factor: 7.561

Review 5.  HIV-1 Tat and Viral Latency: What We Can Learn from Naturally Occurring Sequence Variations.

Authors:  Doreen Kamori; Takamasa Ueno
Journal:  Front Microbiol       Date:  2017-01-30       Impact factor: 5.640

6.  In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication.

Authors:  Matthew D Marsden; Brian A Loy; Xiaomeng Wu; Christina M Ramirez; Adam J Schrier; Danielle Murray; Akira Shimizu; Steven M Ryckbosch; Katherine E Near; Tae-Wook Chun; Paul A Wender; Jerome A Zack
Journal:  PLoS Pathog       Date:  2017-09-21       Impact factor: 6.823

Review 7.  Advancements in Developing Strategies for Sterilizing and Functional HIV Cures.

Authors:  Wei Xu; Haoyang Li; Qian Wang; Chen Hua; Hanzhen Zhang; Weihua Li; Shibo Jiang; Lu Lu
Journal:  Biomed Res Int       Date:  2017-04-26       Impact factor: 3.411

Review 8.  Recent Insights into the HIV/AIDS Pandemic.

Authors:  Juan C Becerra; Lukas S Bildstein; Johannes S Gach
Journal:  Microb Cell       Date:  2016-09-05

9.  The inhibitor apoptosis protein antagonist Debio 1143 Is an attractive HIV-1 latency reversal candidate.

Authors:  Michael Bobardt; Joseph Kuo; Udayan Chatterji; Sumit Chanda; Susan J Little; Norbert Wiedemann; Gregoire Vuagniaux; Philippe A Gallay
Journal:  PLoS One       Date:  2019-02-04       Impact factor: 3.240
  9 in total

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