Literature DB >> 25674932

Inhibitory effects of lupene-derived pentacyclic triterpenoids from Bursera simaruba on HSV-1 and HSV-2 in vitro replication.

Ángel L Álvarez1, Solomon Habtemariam2, Francisco Parra1.   

Abstract

The cytotoxicity and antiviral properties of Bursera simaruba against herpes simplex viruses (HSV-1 and HSV-2) were investigated through a bioactivity-guided isolation protocol. The plant material was fractionated using solvent-solvent partitioning, size-exclusion and thin-layer chromatography. The antiviral compounds present in the most active fractions were identified by means of LC-MS and NMR. Three different methods were compared during the evaluation of antiviral activity of samples. Four lupene-related pentacyclic triterpenes were found to be responsible for the anti-herpesvirus effects of B. simaruba and were isolated from this species for the first time. The selective indexes (SI) of B. simaruba-derived samples ranged from 7.7 to 201.9.

Entities:  

Keywords:  Bursera simaruba; HSV-1; HSV-2; antiviral; pentacyclic triterpenoids

Mesh：

Substances：

Year:  2015        PMID： 25674932     DOI： 10.1080/14786419.2015.1007456

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  7 in total

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Journal:  BMC Complement Altern Med       Date:  2016-10-26       Impact factor: 3.659

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Authors:  Gil Alfonso Magos-Guerrero; Jacinto Santiago-Mejía; Omar F Carrasco
Journal:  J Intercult Ethnopharmacol       Date:  2017-07-12

7.  Phytotherapeutic options for the treatment of COVID-19: A concise viewpoint.

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  7 in total

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