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Literature DB >> 25674279

Intracranial multiple germ cell tumors: a case report and review of literature.

Ping Yang¹, Liang Li², Weiping Kuang¹, Bo Li¹, Bin Zhou¹, Jingjing Yang³, Huiyong Huang⁴.

Abstract

Intracranial multiple germ cell tumors (GCTs) are rare. In this article, we reported a case of intracranial multiple GCTs in an 18-year-old boy with symptoms of psychosis for 8 months also. Tumors in the pineal, sellar region, corpus callosum, bilateral lateral ventricles and fourth ventricle were confirmed by enhanced magnetic resonance imaging (MRI) and stereotactic biopsy. Immunohistochemical analysis results demonstrated that the tumor cells were positive for CD117 and placental alkaline phosphatase (PLAP). The patient was treated by radiotherapy and the prescribed radiation doses were 18 Gy. After near 24 months of follow-up, no local recurrence and distant metastasis has been found.

Entities: Disease Gene Species

Keywords: Intracranial multiple germ cell tumors; corpus callosum; lateral ventricles; pineal; sellar region; symptoms of psychosis

Mesh：

Substances：
Biomarkers, Tumor

Year: 2014 PMID： 25674279 PMCID： PMC4314009

Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625

17 in total

1. Titanium screws as fiducial markers for image-guided stereotactic proton irradiation in pediatric central nervous system tumors: a technical report.

Authors: Philipp R Aldana; Teresa L MacGregor; Hector E James; Robert B Marcus; Daniel J Indelicato
Journal: Pediatr Neurosurg Date: 2010-11-04 Impact factor: 1.162

2. Long-term quality of life and neuropsychologic functioning for patients with CNS germ-cell tumors: from the First International CNS Germ-Cell Tumor Study.

Authors: S A Sands; S J Kellie; A L Davidow; B Diez; J Villablanca; H L Weiner; M C Pietanza; C Balmaceda; J L Finlay
Journal: Neuro Oncol Date: 2001-07 Impact factor: 12.300

3. Metastasis germinomas of the external acoustic meatus: in a 19-year-boy: a case report.

Authors: Rong Zhao; Jiang Wang; Ya Ba; Qiong Zhang
Journal: Int J Clin Exp Pathol Date: 2013-06-15

4. Radiological features of germinoma arising from atypical locations.

Authors: Satoshi Utsuki; Hidehiro Oka; Yoshinori Tanizaki; Kouji Kondo; Kiyotaka Fujii
Journal: Neurol Med Chir (Tokyo) Date: 2005-05 Impact factor: 1.742

5. [Multiple intracranial lesions: a clinicalpathologic study of 62 cases].

Authors: Xiao-juan Zhang; Yue-shan Piao; Li Chen; Guo-cai Tang; Li-feng Wei; Hong Yang; De-hong Lu
Journal: Zhonghua Bing Li Xue Za Zhi Date: 2011-09

6. Unilateral germinomas involving the basal ganglia and thalamus.

Authors: T Kobayashi; N Kageyama; Y Kida; J Yoshida; N Shibuya; K Okamura
Journal: J Neurosurg Date: 1981-07 Impact factor: 5.115

Review 7. A review of soluble c-kit (s-kit) as a novel tumor marker and possible molecular target for the treatment of CNS germinoma.

Authors: Hideo Takeshima; Jun-Ichi Kuratsu
Journal: Surg Neurol Date: 2003-10

Intracranial multiple germ cell tumors: a case report and review of literature.

1. Titanium screws as fiducial markers for image-guided stereotactic proton irradiation in pediatric central nervous system tumors: a technical report.

2. Long-term quality of life and neuropsychologic functioning for patients with CNS germ-cell tumors: from the First International CNS Germ-Cell Tumor Study.

3. Metastasis germinomas of the external acoustic meatus: in a 19-year-boy: a case report.

4. Radiological features of germinoma arising from atypical locations.

5. [Multiple intracranial lesions: a clinicalpathologic study of 62 cases].

6. Unilateral germinomas involving the basal ganglia and thalamus.

Review 7. A review of soluble c-kit (s-kit) as a novel tumor marker and possible molecular target for the treatment of CNS germinoma.

8. Diagnostic significance of soluble c-kit in the cerebrospinal fluid of patients with germ cell tumors.

Review 9. Primary medulla oblongata germinoma: a case report and review of the literature.

10. Primary intracranial germ cell tumors.

1. Germinoma with an extensive rhabdoid cell component centered at the corpus callosum.

2. Intracranial germinoma in the lateral ventricle with polydipsia and polyuria: a case report and literature review.