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Literature DB >> 25674211

Enhanced expression of long noncoding RNA CARLo-5 is associated with the development of gastric cancer.

Yan Zhang¹, Mingzhe Ma², Weiyong Liu³, Wenping Ding⁴, Honggang Yu⁵.

Abstract

The identification of cancer-associated long non-coding RNAs and the investigation of their molecular and biological functions are vital for understanding the molecular biology and progression of cancer. The CARLo-5, a newly identified long non-coding RNA, was found to be upregulated in colon cancer. However, little is known about its role in gastric cancer. In the present study, a great upregulation of CARLo-5 was observed in gastric cancer compared to paired adjacent normal tissues. Knockdown of CARLo-5 in gastric cancer cell lines significantly inhibited the cell proliferation via inducing G0/G1 cell-cycle arrest and apoptosis. Furthermore, ERK/MAPK pathway was found to be inactivated in the gastric cells after CARLo-5 knockdown. These results indicated that CARLo-5 might serve as a pro-oncogenic lncRNA that promotes proliferation of gastric cancer and activates the ERK/MAPK pathway.

Entities: Disease Gene

Keywords: CARLo-5; ERK; MAPK; gastric cancer; lncRNA; proliferation

Mesh：

Substances：

Year: 2014 PMID： 25674211 PMCID： PMC4314006

Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625

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Enhanced expression of long noncoding RNA CARLo-5 is associated with the development of gastric cancer.

1. Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells.

Review 2. Long non-coding RNAs: a new frontier in the study of human diseases.

3. HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway.

Review 4. Emerging trends of long non-coding RNAs in gene activation.

Review 5. Present and future status of gastric cancer surgery.

6. Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans.

7. Hepatitis B virus X protein (HBx)-related long noncoding RNA (lncRNA) down-regulated expression by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin.

Review 8. Guidelines for the management of oesophageal and gastric cancer.

Review 9. Role of p38 MAP Kinase Signal Transduction in Solid Tumors.

Review 10. miRNA dysregulation in cancer: towards a mechanistic understanding.

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2. LncRNA LINC00152 promoted glioblastoma progression through targeting the miR-107 expression.

Review 3. Recent advances in the molecular diagnostics of gastric cancer.

4. Long non-coding RNA CCAT1 is overexpressed in oral squamous cell carcinomas and predicts poor prognosis.

5. Long noncoding RNA MALAT1 promotes uveal melanoma cell growth and invasion by silencing of miR-140.

Review 6. CCAT1: a pivotal oncogenic long non-coding RNA in human cancers.

7. Hypoxia/lncRNA-AK123072/EGFR pathway induced metastasis and invasion in gastric cancer.

Review 8. Emerging roles of non-coding RNAs in gastric cancer: Pathogenesis and clinical implications.

Review 9. Dysregulation of non-coding RNAs in gastric cancer.

10. Long noncoding RNAs in cancer: from function to translation.