Literature DB >> 25673722

A mutant H3N2 influenza virus uses an alternative activation mechanism in TMPRSS2 knockout mice by loss of an oligosaccharide in the hemagglutinin stalk region.

Kouji Sakai1, Tsuyoshi Sekizuka2, Yasushi Ami3, Noriko Nakajima4, Minori Kitazawa5, Yuko Sato4, Katsuhiro Nakajima5, Masaki Anraku6, Toru Kubota6, Katsuhiro Komase6, Kazuaki Takehara7, Hideki Hasegawa4, Takato Odagiri8, Masato Tashiro8, Makoto Kuroda2, Makoto Takeda6.   

Abstract

The host protease TMPRSS2 plays an essential role in proteolytic activation of the influenza A virus (IAV) hemagglutinin (HA) protein possessing a monobasic cleavage site. However, after passages in TMPRSS2 knockout mice, an H3N2 subtype IAV began to undergo cleavage activation of HA, showing high virulence in the mice due to the loss of an oligosaccharide at position 8 in the HA stalk region. Thus, the H3N2 IAV acquired cleavability by an alternative HA activation mechanism/protease(s).
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25673722      PMCID： PMC4403495          DOI： 10.1128/JVI.00124-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

1.  Sequence requirements for cleavage activation of influenza virus hemagglutinin expressed in mammalian cells.

Authors:  Y Kawaoka; R G Webster
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

2.  Mutations at the cleavage site of the hemagglutinin after the pathogenicity of influenza virus A/chick/Penn/83 (H5N2).

Authors:  M Ohuchi; M Orlich; R Ohuchi; B E Simpson; W Garten; H D Klenk; R Rott
Journal:  Virology       Date:  1989-02       Impact factor: 3.616

3.  The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses.

Authors:  Kouji Sakai; Yasushi Ami; Maino Tahara; Toru Kubota; Masaki Anraku; Masako Abe; Noriko Nakajima; Tsuyoshi Sekizuka; Kazuya Shirato; Yuriko Suzaki; Akira Ainai; Yuichiro Nakatsu; Kazuhiko Kanou; Kazuya Nakamura; Tadaki Suzuki; Katsuhiro Komase; Eri Nobusawa; Katsumi Maenaka; Makoto Kuroda; Hideki Hasegawa; Yoshihiro Kawaoka; Masato Tashiro; Makoto Takeda
Journal:  J Virol       Date:  2014-03-05       Impact factor: 5.103

4.  Molecular changes in A/Chicken/Pennsylvania/83 (H5N2) influenza virus associated with acquisition of virulence.

Authors:  R G Webster; Y Kawaoka; W J Bean
Journal:  Virology       Date:  1986-03       Impact factor: 3.616

5.  Comparison of complete amino acid sequences and receptor-binding properties among 13 serotypes of hemagglutinins of influenza A viruses.

Authors:  E Nobusawa; T Aoyama; H Kato; Y Suzuki; Y Tateno; K Nakajima
Journal:  Virology       Date:  1991-06       Impact factor: 3.616

6.  Structural features influencing hemagglutinin cleavability in a human influenza A virus.

Authors:  Y Kawaoka
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103

7.  Glycosylation affects cleavage of an H5N2 influenza virus hemagglutinin and regulates virulence.

Authors:  K L Deshpande; V A Fried; M Ando; R G Webster
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

8.  Interplay between carbohydrate in the stalk and the length of the connecting peptide determines the cleavability of influenza virus hemagglutinin.

Authors:  Y Kawaoka; R G Webster
Journal:  J Virol       Date:  1989-08       Impact factor: 5.103

9.  Is virulence of H5N2 influenza viruses in chickens associated with loss of carbohydrate from the hemagglutinin?

Authors:  Y Kawaoka; C W Naeve; R G Webster
Journal:  Virology       Date:  1984-12       Impact factor: 3.616

10.  Evolution of the A/Chicken/Pennsylvania/83 (H5N2) influenza virus.

Authors:  Y Kawaoka; R G Webster
Journal:  Virology       Date:  1985-10-15       Impact factor: 3.616
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  19 in total

1.  TMPRSS2 Is the Major Activating Protease of Influenza A Virus in Primary Human Airway Cells and Influenza B Virus in Human Type II Pneumocytes.

Authors:  Hannah Limburg; Anne Harbig; Dorothea Bestle; David A Stein; Hong M Moulton; Julia Jaeger; Harshavardhan Janga; Kornelia Hardes; Janine Koepke; Leon Schulte; Andreas Rembert Koczulla; Bernd Schmeck; Hans-Dieter Klenk; Eva Böttcher-Friebertshäuser
Journal:  J Virol       Date:  2019-10-15       Impact factor: 5.103

2.  Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways.

Authors:  Manon Laporte; Annelies Stevaert; Valerie Raeymaekers; Talitha Boogaerts; Inga Nehlmeier; Winston Chiu; Mohammed Benkheil; Bart Vanaudenaerde; Stefan Pöhlmann; Lieve Naesens
Journal:  J Virol       Date:  2019-12-12       Impact factor: 5.103

3.  Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection.

Authors:  Yousuke Fujimoto; Shunji Hasegawa; Takeshi Matsushige; Hiroyuki Wakiguchi; Tamaki Nakamura; Hideki Hasegawa; Noriko Nakajima; Akira Ainai; Atsunori Oga; Hiroshi Itoh; Komei Shirabe; Shoichi Toda; Ryo Atsuta; Tsuneo Morishima; Shouichi Ohga
Journal:  Sci Rep       Date:  2017-08-22       Impact factor: 4.379

4.  Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin.

Authors:  Pawel Zmora; Paulina Molau-Blazejewska; Stephanie Bertram; Kerstin Walendy-Gnirß; Inga Nehlmeier; Anika Hartleib; Anna-Sophie Moldenhauer; Sebastian Konzok; Susann Dehmel; Katherina Sewald; Constantin Brinkmann; Christoph Curths; Sascha Knauf; Jens Gruber; Kerstin Mätz-Rensing; Franziska Dahlmann; Armin Braun; Stefan Pöhlmann
Journal:  PLoS One       Date:  2017-05-11       Impact factor: 3.240

5.  Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells.

Authors:  Hiroki Kimura; Dave Francisco; Michelle Conway; Fernando D Martinez; Donata Vercelli; Francesca Polverino; Dean Billheimer; Monica Kraft
Journal:  J Allergy Clin Immunol       Date:  2020-05-15       Impact factor: 10.793

6.  Hemagglutinins of Avian Influenza Viruses Are Proteolytically Activated by TMPRSS2 in Human and Murine Airway Cells.

Authors:  Dorothea Bestle; Hannah Limburg; Diana Kruhl; Anne Harbig; David A Stein; Hong Moulton; Mikhail Matrosovich; Elsayed M Abdelwhab; Jürgen Stech; Eva Böttcher-Friebertshäuser
Journal:  J Virol       Date:  2021-07-28       Impact factor: 5.103

Review 7.  Animal Models for Influenza Research: Strengths and Weaknesses.

Authors:  Thi-Quyen Nguyen; Rare Rollon; Young-Ki Choi
Journal:  Viruses       Date:  2021-05-28       Impact factor: 5.048

8.  TMPRSS2 Independency for Haemagglutinin Cleavage In Vivo Differentiates Influenza B Virus from Influenza A Virus.

Authors:  Kouji Sakai; Yasushi Ami; Noriko Nakajima; Katsuhiro Nakajima; Minori Kitazawa; Masaki Anraku; Ikuyo Takayama; Natthanan Sangsriratanakul; Miyuki Komura; Yuko Sato; Hideki Asanuma; Emi Takashita; Katsuhiro Komase; Kazuaki Takehara; Masato Tashiro; Hideki Hasegawa; Takato Odagiri; Makoto Takeda
Journal:  Sci Rep       Date:  2016-07-08       Impact factor: 4.379

Review 9.  Gene of the month: TMPRSS2 (transmembrane serine protease 2).

Authors:  Michelle Thunders; Brett Delahunt
Journal:  J Clin Pathol       Date:  2020-09-01       Impact factor: 3.411

Review 10.  Sex-related differences in COVID-19 lethality.

Authors:  Claudia Penna; Valentina Mercurio; Carlo G Tocchetti; Pasquale Pagliaro
Journal:  Br J Pharmacol       Date:  2020-08-05       Impact factor: 9.473
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