Gender differences in the brain: are they relevant to the pathogenesis of schizophrenia?

Gender differences are present in the clinical expression of schizophrenia, age of onset, course of illness, and response to pharmacologic treatment. These differences are not surprising in view of the normal gender differences in brain growth, differentiation, adult brain structure, and neurochemistry. The present review examines what is presently known about brain gender differences, and whether this information is consistent with the published reports of brain functional and morphological abnormalities in schizophrenia. Whether gender differences in the brain can explain the gender differences in clinical aspects of the disorder remains unknown.